The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours

Breast Cancer Research : BCR
Arian LundbergNicholas P Tobin

Abstract

Use of cyclin D1 (CCND1) gene amplification as a breast cancer biomarker has been hampered by conflicting assessments of the relationship between cyclin D1 protein levels and patient survival. Here, we aimed to clarify its prognostic and treatment predictive potential through comprehensive long-term survival analyses. CCND1 amplification was assessed using SNP arrays from two cohorts of 1965 and 340 patients with matching gene expression array and clinical follow-up data of over 15 years. Kaplan-Meier and multivariable Cox regression analyses were used to determine survival differences between CCND1 amplified vs. non-amplified tumours in clinically relevant patient sets, within PAM50 subtypes and within treatment-specific subgroups. Boxplots and differential gene expression analyses were performed to assess differences between amplified vs. non-amplified tumours within PAM50 subtypes. When combining both cohorts, worse survival was found for patients with CCND1-amplified tumours in luminal A (HR = 1.68; 95% CI, 1.15-2.46), luminal B (1.37; 1.01-1.86) and ER+/LN-/HER2- (1.66; 1.14-2.41) subgroups. In gene expression analysis, CCND1-amplified luminal A tumours showed increased proliferation (P < 0.001) and decreased progesterone ...Continue Reading

References

Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·H MatsushimeC J Sherr
May 1, 1994·International Journal of Cancer. Journal International Du Cancer·J BartkovaJ Bartek
Apr 22, 1996·International Journal of Cancer. Journal International Du Cancer·C GillettD Barnes
Sep 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P PelosioG Gasparini
Oct 12, 2004·Biostatistics·Adam B OlshenMichael Wigler
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew Arnold, Alexandros Papanikolaou
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Jan 31, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wedad M Hanna, Kevin Kwok
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Margaretha RudasUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
Dec 24, 2009·Nature Reviews. Cancer·Thomas SantariusColin S Cooper
Feb 19, 2010·Nature·Rameen BeroukhimMatthew Meyerson
Jul 8, 2011·Nature Reviews. Cancer·Elizabeth A MusgroveRobert L Sutherland
Jan 1, 2010·Cancer Biomarkers : Section a of Disease Markers·Matthias ChoschzickRonald Simon
Sep 15, 2012·Breast Cancer Research and Treatment·Mary Anne QuintayoJohn M S Bartlett
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Dec 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aleix PratCharles M Perou
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Nov 11, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoK A Gelmon
Oct 4, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicholas P TobinUNKNOWN TEX Trialists Group
Oct 4, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arian LundbergNicholas P Tobin

❮ Previous
Next ❯

Citations

Feb 15, 2020·Molecular Oncology·Mieke R Van BockstalCarolien H M van Deurzen
Mar 27, 2020·Medical Sciences : Open Access Journal·Ugo TestaElvira Pelosi
Aug 29, 2019·PloS One·Daniela FerreiraRaquel Chaves
Jul 23, 2020·Frontiers in Oncology·Zhonghua TaoXichun Hu
Jan 20, 2021·Nature Medicine·Theresa E HickeyWayne D Tilley
Feb 11, 2021·In Vitro Cellular & Developmental Biology. Animal·Jian-Zhong Wang, Bao-Hui Zhao
Jan 28, 2021·Cancers·Aditi S KhatpeHarikrishna Nakshatri
Apr 12, 2021·Pathology, Research and Practice·Nataša Todorović-RakovićMarko Radulovic
Jun 29, 2021·Expert Review of Anticancer Therapy·Komal JhaveriGeoffrey I Shapiro
Dec 4, 2021·Frontiers in Oncology·Junmei HaoFangrong Tang

❮ Previous
Next ❯

Datasets Mentioned

BETA
EGAS00000000083
GSE48091

Methods Mentioned

BETA
genotyping

Software Mentioned

TransATAC
Genomic Identification of Significant Targets in Cancer 2 . 0 ...
R DNAcopy package
METABRIC
GenomeStudio
affymetrix package
R aroma
R
R package Limma
GISTIC

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Current Breast Cancer Reports
Nicholas P Tobin, Jonas Bergh
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Nicholas P TobinJonas Bergh
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
E BalcerczakM Mirowski
© 2022 Meta ULC. All rights reserved