The Long Terminal Repeat Retrotransposons Tf1 and Tf2 of Schizosaccharomyces pombe

Microbiology Spectrum
Caroline Esnault, Henry L Levin

Abstract

The long terminal repeat (LTR) retrotransposons Tf1 and Tf2 of Schizosaccharomyces pombe are active mobile elements of the Ty3/gypsy family. The mobilization of these retrotransposons depends on particle formation, reverse transcription and integration, processes typical of other LTR retrotransposons. However, Tf1 and Tf2 are distinct from other LTR elements in that they assemble virus-like particles from a single primary translation product, initiate reverse transcription with an unusual self-priming mechanism, and, in the case of Tf1, integrate with a pattern that favors specific promoters of RNA pol II-transcribed genes. To avoid the chromosome instability and genome damage that results from increased copy number, S. pombe applies a variety of defense mechanisms that restrict Tf1 and Tf2 activity. The mRNA of the Tf elements is eliminated by an exosome-based pathway when cells are in favorable conditions whereas nutrient deprivation triggers an RNA interference-dependent pathway that results in the heterochromatization of the elements. Interestingly, Tf1 integrates into the promoters of stress-induced genes and these insertions are capable of increasing the expression of adjacent genes. These properties of Tf1 transposition ...Continue Reading

References

Mar 1, 1992·Molecular & General Genetics : MGG·M TudorK O'Hare
Dec 1, 1990·Molecular and Cellular Biology·H L LevinJ D Boeke
Nov 1, 1996·Science·P SanMiguelJ L Bennetzen
Dec 1, 1996·Current Opinion in Genetics & Development·A F Smit
Jan 10, 1997·Cell·H L Levin
Jun 29, 2001·Journal of Molecular Evolution·M ButlerR Poulter
Feb 23, 2002·Nature·V WoodL Cerrutti
Jul 5, 2002·Genome Research·Olivier LespinetL Aravind
Aug 6, 2002·Nature Genetics·Juan MataJürg Bähler
Oct 14, 2003·Eukaryotic Cell·Raynald de LahondèsBenoit Arcangioli
Aug 4, 2004·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Hiroshi MasumotoJun-Ichirou Ohzeki
Jan 6, 2005·Molecular and Cellular Biology·Klavs R HansenGeneviève Thon
Sep 17, 2005·Molecular and Cellular Biology·Eva Mejía-RamírezPablo Hernández
Oct 1, 2005·The Journal of Biological Chemistry·Gregor Krings, Deepak Bastia
Nov 12, 2005·Journal of Virology·Angela Atwood-MooreHenry L Levin
Mar 17, 2007·Nature Reviews. Genetics·R Keith Slotkin, Robert Martienssen

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Citations

Dec 14, 2018·Genome Research·Caroline EsnaultHenry L Levin
Aug 9, 2017·Annual Review of Virology·Marilyn J Roossinck, Edelio R Bazán
Nov 19, 2021·Genome Biology and Evolution·Yan WangGuan-Zhu Han

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