Abstract
In patients with diabetes mellitus, the urinary microalbumin-to-urine creatinine ratio (UACR) can not only predict the occurrence of diabetic nephropathy but also can be a risk factor for cardiovascular disease and renal function damage. Current studies on subclinical hypothyroidism (SCH) and UACR are mainly cross-sectional studies, and the results suggest that SCH is an independent risk factor for UACR. To further explore the longitudinal effect of SCH on UACR, we carried out this study. This was a retrospective cohort study including 46 patients with type 2 diabetes mellitus and SCH in the Department of Endocrinology, The Affiliated Huai'an Hospital of Xuzhou Medical University from January 2013 to April 2018. At the same time, 96 patients with type 2 diabetes mellitus and euthyroid were chosen according to 1:2 approximately matched with age, sex and duration of diabetes mellitus. Univariate analysis, stratified analysis, and multiple linear regression analysis were used to investigate the effect of SCH on ΔUACR(ΔUACR = UACR after 1 year - baseline UACR) in patients with type 2 diabetes mellitus. There was no significant difference between the baseline UACR, (p > 0.05). However, the ΔUACR was significantly higher in SCH group...Continue Reading
References
Jul 20, 2005·Treatments in Endocrinology·Emiliano A PalmieriBernadette Biondi
Sep 28, 2006·The Journal of Clinical Endocrinology and Metabolism·George DimitriadisSotirios A Raptis
Oct 24, 2008·Diabetes Care·David M NathanUNKNOWN European Association for Study of Diabetes
Jan 15, 2009·European Journal of Endocrinology·Eirini MaratouGeorge Dimitriadis
May 9, 2009·European Journal of Endocrinology·Bernadette BiondiGaetano Lombardi
Apr 6, 2011·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·J J DíezP Iglesias
Sep 20, 2011·Diabetes Research and Clinical Practice·Tetsuyuki YasudaIichiro Shimomura
Jul 31, 2012·Lancet·Terence J QuinnDavid J Stott
Aug 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Bernadette Biondi
Apr 2, 2013·Maturitas·Bamini GopinathPaul Mitchell
Jan 10, 2014·Diabetes & Metabolism Journal·Mervat M El-EshmawyIbrahim A Abdel Aal
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Ane Garmendia MadariagaJuan C Galofré
Aug 8, 2014·Endocrine Journal·Shinya FurukawaTakeshi Tanigawa
Aug 14, 2015·PloS One·Cheng HanWeiping Teng
Nov 20, 2015·The Journal of Clinical Endocrinology and Metabolism·Hanne F FleinerBjørn O Åsvold
Oct 16, 2016·Journal of Endocrinological Investigation·N MansourniaE Hazrati
Jun 5, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Qi QiJing-Yun Zhang
Sep 19, 2017·The American Journal of the Medical Sciences·Tushar A TulianiLuis Afonso
Oct 5, 2017·The New England Journal of Medicine·Robin P Peeters
Oct 6, 2017·The New England Journal of Medicine·Pedro W Rosario
Dec 8, 2017·JAMA Cardiology·Benjamin M SciricaEugene Braunwald
Dec 28, 2017·Diabetes & Metabolic Syndrome·Maaz OzairJamal Ahmad
Feb 3, 2018·Scientific Reports·Yi-Cheng ChangYu-Kang Tu
Jun 1, 2018·Nutrients·Gustavo R G AndradeDirce M Marchioni
Jul 7, 2018·Thyroid : Official Journal of the American Thyroid Association·Shinje MoonYoung Joo Park
Jul 22, 2018·Diabetes Care·M Loredana MarcovecchioUNKNOWN Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Aug 18, 2018·Annals of Clinical Biochemistry·Gautam DasOnyebuchi Okosieme