The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia.

Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses
Mary C HookeWei Pan

Abstract

Background: During treatment for acute lymphoblastic leukemia (ALL), children report co-occurring symptoms of fatigue, sleep disturbance, pain, nausea, and depression as a symptom cluster. Central nervous system-directed ALL therapies also put children at risk for cognitive impairments. Cancer therapies can cause an increase in oxidative stress, which may contribute to treatment-related symptoms. This study examined the longitudinal relationships between biomarkers of oxidative stress in the cerebrospinal fluid, the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L), and cognition, in children over the first year of ALL treatment. Methods: Glutathione (GSH) biomarkers of oxidative stress were measured in cerebrospinal fluid collected during treatment lumbar punctures. GSH biomarkers, symptoms, and cognitive function of 132 children aged 3 to 18 years were evaluated at four time points during the first year of leukemia treatment. Participants, 7 years and older, completed self-report measures, and parents reported for younger children. Cognitive function measurements for all participants were completed by parents. A longitudinal parallel-process model was used to explore the influence of the initial measurement and the subsequen...Continue Reading

References

Jan 1, 1988·American Journal of Industrial Medicine·A D McDonaldJ C McDonald

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Citations

Apr 23, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·AnnaLynn M Williams, Peter D Cole

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Clinical Trials Mentioned

NCT01708421

Software Mentioned

NIH Toolbox®
Cogstate
SEM
SPSS Amos
SAS

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