The Look AHEAD Trial: A Review and Discussion Of Its Outcomes

Current Nutrition Reports
Xavier Pi-Sunyer

Abstract

The LookAhead trial was a randomized controlled trial comparing an Intensive Lifestyle Intervention (ILI) to a Diabetes Support and Education (DSE) in overweight and obese type 2 diabetes patients to track the development of cardiovascular disease over time. The triaI intervention was stopped for futility after a median follow-up of 9.6 years. While there was a differential effect on weight loss and fitness between the two groups, there was no effect on cardiovascular outcomes. Cardiovascular events were less than half the projected rate per year in the DSE group: thus there was a very low over-all rate of events in both groups. There were many other health benefits of ILI, including improved biomarkers of glucose and lipid control, less sleep apnea, lower liver fat, less depression, improved insulin sensitivity, less urinary incontinence, less kidney disease, reduced need of diabetes medications, maintenance of physical mobility, improved quality of life and lower costs.

References

Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
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Jun 13, 2013·Diabetes Care·Rena R WingUNKNOWN Sexual Dysfunction Subgroup of the Look AHEAD Research Group
Jun 26, 2013·The New England Journal of Medicine·Rena R WingSusan Z Yanovski

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Citations

Dec 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniRiccardo Dalle Grave
Jul 24, 2015·International Forum of Allergy & Rhinology·Toby O SteeleTimothy L Smith
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