The loss of copper is associated with the increase in copper metabolism MURR domain 1 in ischemic hearts of mice

Experimental Biology and Medicine
Kui LiY James Kang

Abstract

The distribution of copper (Cu) in the biological system is regulated by Cu transporters and chaperones. It has been known for a long time that myocardial ischemia is accompanied by the loss of Cu from the heart, but the mechanism by which this occurs remains unknown. The present study was undertaken to understand the relationship between Cu loss and alterations in Cu transporters during the pathogenesis of myocardial ischemia. Male mice (C57 BL/6J) were subjected to left anterior descending (LAD) coronary artery ligation to induce myocardial ischemia. Changes in Cu concentrations in serum and hearts were determined from blood and tissue samples harvested at different time points for a total of 28 days after the operation. Cu concentrations in the ischemic myocardium were continuously decreased starting at the fourth day after LAD artery ligation, gradually depleted by more than 80% of the normal level at the 10th day, and remained at the lowest level (about 20% of normal levels) thereafter. Serum Cu concentrations were correspondingly increased starting at the fourth day, reached to the highest level between day 7 and 10, and gradually recovered to the normal level until 21st day after the operation. Along with the same time c...Continue Reading

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Citations

Feb 15, 2019·Metallomics : Integrated Biometal Science·Chunyan FuY James Kang
Mar 10, 2020·Experimental Biology and Medicine·Ying XiaoY James Kang
Nov 30, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Dan YangY James Kang
Oct 25, 2020·Nutrients·Antonio P Arenas de LarrivaJavier Delgado-Lista
Mar 4, 2021·Experimental Biology and Medicine·Chen LiY James Kang
Apr 27, 2021·Cardiovascular Toxicology·Chen LiY James Kang

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Methods Mentioned

BETA
atomic absorption spectrometry

Software Mentioned

Image
Pro Plus
GraphPad prism
IPP

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