PMID: 9651475Jul 4, 1998Paper

The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud

Mechanisms of Development
S M BellW J Scott

Abstract

We have characterized the early stages of murine hindlimb morphogenesis in the legless (lgl)mutant and non-mutant littermates. Initially the entire ventral ectoderm expresses many genetic markers characteristic of the AER (en-1, fgf-8, msx-2, dlx-2, cd44, and cx-43). Subsequently, the expression domain of most of these genes is restricted to the thickened ectoderm of the disto-ventral limb margin prior to forming an AER. In lgl, the expression of these genes is initiated but not maintained and the disto-ventral marginal ectoderm does not thicken. In contrast, Wnt7a expression is initiated and maintained in the dorsal ectoderm. The limb mesenchyme of lgl and non-mutant embryos initially expresses lmx-1b and fgf-10 uniformly. As the ventro-distal marginal ectoderm thickens, lmx-1b is progressively dorsally restricted in non-mutants but continues to be expressed ventrally in lgl hindlimb buds. These data suggest that establishment of a dorso-ventral ectodermal interface is not sufficient for AER formation and that restriction of lmx-1b to the dorsal mesenchyme is coordinately linked to AER formation.

References

Sep 1, 1979·The Journal of Experimental Zoology·K V PrahladW E Briles
Oct 1, 1991·Developmental Biology·N Wanek, S V Bryant
Feb 1, 1990·The Journal of Experimental Zoology·J D McNeishW J Scott
Jan 1, 1989·The Journal of Experimental Zoology·N WanekS V Bryant
Aug 12, 1988·Science·J D McNeishS S Potter
May 1, 1974·Developmental Biology·J W Saunders, C Reuss
Oct 28, 1994·Biochemical and Biophysical Research Communications·H OhuchiS Noji
Nov 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M P SavageJ F Fallon
Jan 1, 1993·Methods in Enzymology·D G Wilkinson, M A Nieto
Jul 25, 1996·Nature·C A LoomisA L Joyner
Jun 8, 1996·Annals of the New York Academy of Sciences·D WainwrightP Herrlich
Aug 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D L ChapmanV E Papaioannou
Oct 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Q YuB P Toole
Oct 10, 1997·Cell·R L Johnson, C J Tabin
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Y LanT Gridley
Aug 26, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S M BellT Gridley
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

❮ Previous
Next ❯

Citations

Oct 27, 1999·Mechanisms of Development·S M BellW J Scott
Nov 1, 2001·Annual Review of Cell and Developmental Biology·J Capdevila, J C Izpisúa Belmonte
Oct 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sheila M BellWilliam J Scott
Mar 21, 2009·Genesis : the Journal of Genetics and Development·Qiong QiuRandy L Johnson
Jun 5, 2003·Mechanisms of Development·Sheila M BellWilliam J Scott
Jul 20, 2002·Mechanisms of Development·Muriel Altabef, Cheryll Tickle
Apr 22, 2015·Nature Cell Biology·Kimberly LauSevan Hopyan
Apr 15, 2004·Developmental Biology·Chi-Kuang Leo WangRobert A Kosher
Jun 12, 2012·Developmental Biology·Adam H Rabinowitz, Steven A Vokes
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Yingzi Yang
Apr 30, 2017·Development·Endika HaroKerby C Oberg
Apr 29, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sheila M BellWilliam J Scott
Sep 24, 2004·The Journal of Biological Chemistry·Richard J WenstrupDavid E Birk
Feb 13, 1999·Cell·B L Hogan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.