The loudness dependence of the auditory evoked potential (LDAEP) as an in vivo biomarker of central serotonergic function in humans: rationale, evaluation and review of findings

Human Psychopharmacology
Barry O'NeillPradeep J Nathan

Abstract

The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a valid means of non-invasively assessing in vivo central serotonin (5-hydroxytryptamine, 5-HT) function in humans. The specificity and sensitivity of the LDAEP to changes in 5-HT neurotransmission have recently been explored directly in a number of pharmacological and genetic studies. Subsequently, this review was undertaken in an attempt to critically evaluate the potential role of the LDAEP as a marker of the central 5-HT function. Findings from clinical, experimental animal and human studies examining the relationship between the LDAEP and the 5-HT system as well as other neurochemical systems including dopaminergic, glutamatergic and the cholinergic systems were reviewed. The majority of evidence for an association between the LDAEP and 5-HT has come from animal studies. Indirect studies in clinical disorders of presumed serotonergic dysfunction have been circumstantial and inconsistent with more recent investigations utilising direct genetic association studies also providing conflicting reports. Pharmacological studies in humans provide overwhelming evidence that the LDAEP is insensitive to acute changes in 5-HT function, with additiona...Continue Reading

References

Mar 1, 1992·Arquivos de neuro-psiquiatria·S Camposano, F Lolas
Jan 1, 1990·Journal of Cardiovascular Pharmacology·G M Tyce
Aug 1, 1992·Alcoholism, Clinical and Experimental Research·K YoshimotoT K Li
May 1, 1992·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·M T Carrillo-de-la-Peña
Jan 1, 1990·Annals of the New York Academy of Sciences·D L Murphy
Mar 1, 1990·Biological Psychiatry·U HegerlB Müller-Oerlinghausen
Feb 15, 1988·Experientia·A Pletscher
Jan 1, 1985·Psychopharmacology·S N YoungF R Ervin
Sep 1, 1971·Psychophysiology·M Buchsbaum
Jan 1, 1968·Psychosomatic Medicine·M Buchsbaum, J Silverman
Jan 1, 1981·Neuropsychobiology·L von Knorring, C Perris
Aug 1, 1984·Biological Psychology·J PrescottJ H Gruzelier
Jul 1, 1995·Archives of General Psychiatry·H K ManjiR H Lenox
Apr 1, 1995·Biological Psychiatry·U HegerlD Mrowinski
Jan 1, 1993·Progress in Biophysics and Molecular Biology·M C Boadle-Biber
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S NishizawaM Diksic
Jan 1, 1997·Journal of Psychopharmacology·J G ReillyA H Young
Aug 7, 1998·Biological Psychiatry·I Lucki
Aug 27, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M J Morgan
Dec 1, 1998·Neuroscience Letters·F BellivierJ L Laplanche
Dec 23, 1998·Biological Psychiatry·K M Connor, J R Davidson
Feb 13, 1999·International Clinical Psychopharmacology·G GerraR Delsignore

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Citations

Dec 8, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Florence HagenmullerWolfram Kawohl
Oct 13, 2010·Biochemical Pharmacology·Steven C LeiserDavid M Devilbiss
Jan 20, 2010·Psychiatry Research·Markus Röhl, Stefan Uppenkamp
May 10, 2012·Neuropharmacology·Anusha BaskaranRoger S McIntyre
Nov 26, 2010·Journal of Psychopharmacology·Hamid AlhajR Hamish McAllister-Williams
Apr 2, 2011·Human Psychopharmacology·Jessica L OlivaPradeep J Nathan
Oct 6, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Jeffrey D LewineBruce J Simon
Jun 3, 2011·Harvard Review of Psychiatry·Dan Vlad Iosifescu
Dec 9, 2020·The European Journal of Neuroscience·Jamie A O'Reilly, Bernard A Conway
Apr 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Sunkyung YoonSeung-Hwan Lee

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