PMID: 1607898Jun 11, 1992Paper

The low cholesterol-mortality association in a national cohort

Journal of Clinical Epidemiology
T HarrisA Schatzkin

Abstract

The relationship of low serum cholesterol and mortality was examined in data from the NHANES I Epidemiologic Followup Study (NHEFS) for 10,295 persons aged 35-74, 5833 women with 1281 deaths and 4462 men with 1748 deaths (mean (followup = 14.1 years). Serum cholesterol below 4.1 mmol/l was associated with increased risk of death in comparison with serum cholesterol of 4.1-5.1 mmol/l (relative risk (RR) for women = 1.7, 95% confidence interval (CI) = (1.2, 2.3); for men RR = 1.4, CI = (1.1, 1.7)). However, the low serum cholesterol-mortality relationship was modified by time, age, and among older persons, activity level. The low serum cholesterol-mortality association was strongest in the first 10 years of followup. Moreover, this relationship occurred primarily among older persons (RR for low serum cholesterol for women 35-59 = 1.0 (0.6, 1.8), for women 70-74, RR = 2.1 (1.2, 3.7); RR for low serum cholesterol for men 35-59 = 1.2 (0.8, 2.0), for men 70-74, RR = 1.9 (1.3, 2.7)). Among older persons, however, the low serum cholesterol-mortality association was confined only to those with low activity at baseline. Factors related to underlying health status, rather than a mortality-enhancing effect of low cholesterol, likely accoun...Continue Reading

Citations

Dec 1, 1994·The Clinical Investigator·E WindlerH Greten
Nov 1, 1993·Cardiovascular Drugs and Therapy·J E Rossouw, A M Gotto
Aug 1, 1994·Atherosclerosis·J C LaRosa
Jul 1, 1995·Journal of Psychosomatic Research·J Wardle
Oct 7, 2004·Journal of Psychosomatic Research·Raymonde A BrownShari R Waldstein
Mar 27, 1997·The New England Journal of Medicine·W R Hazzard, W H Ettinger
Apr 29, 1998·Experimental Aging Research·P RanieriM Trabucchi
Feb 1, 1996·Australian and New Zealand Journal of Medicine·L A SimonsJ Simons
May 21, 1994·BMJ : British Medical Journal·S L BrownF J Kohout
Aug 12, 1995·BMJ : British Medical Journal·G WannametheeM Walker
Sep 23, 1995·BMJ : British Medical Journal·W M Monique Verschuren, D Kromhout
Jan 1, 1996·International Journal of Behavioral Medicine·K W DavidsonD Zitner
Mar 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·B J Mosinger
Feb 28, 2006·Medical Hypotheses·Carlos Pérez-Guzmán, Mario H Vargas
Oct 24, 2009·Internal Medicine Journal·L A SimonsJ McCallum
Jan 3, 2013·Pediatric Blood & Cancer·Soheir S Adam, Carolyn Hoppe
May 1, 1996·Journal of the American Geriatrics Society·D K MillerJ E Morley
Jan 1, 1996·Journal of the American Geriatrics Society·M D GrantT P Miles
Mar 1, 1995·Journal of the American Geriatrics Society·W H EttingerE Kouba
Jun 1, 2010·Archives of Physical Medicine and Rehabilitation·Shin-Liang PanTony Hsiu-Hsi Chen
Oct 1, 1994·The American Journal of the Medical Sciences·C J GlueckJ Speirs
Sep 1, 1994·Journal of Clinical Epidemiology·H IsoY Komachi
Oct 8, 1997·Psychosomatic Medicine·M HorstenK Orth-Gomer
Oct 1, 1993·Circulation·J StamlerD Steinberg
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Richard B HorensteinLori Mosca
Nov 30, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Joseph Murray, David P Farrington
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·Silvia B MatiacevichM Pilar Buera
Apr 20, 2006·Critical Reviews in Food Science and Nutrition·Christine M OliverRoger A Stanley
Jul 11, 2006·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Gary G BennettKaren M Emmons
Jan 1, 1997·Journal of Atherosclerosis and Thrombosis·P CullenG Assmann
Nov 5, 2019·Journal of Food Biochemistry·Md Anisur Rahman MazumderRanganathan Thottiam Vasudevan
Apr 7, 2004·Journal of the American Geriatrics Society·Tamara B Harris
Nov 1, 1995·The Proceedings of the Nutrition Society·W A van StaverenC de Graaf
Feb 1, 2021·Cardiovascular Diabetology·Emanuela OrsiUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Sep 1, 1993·Metabolism: Clinical and Experimental·M F MuldoonP G Kaufmann

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