The Lpt ABC transporter for lipopolysaccharide export to the cell surface

Research in Microbiology
Paola SperandeoAlessandra Polissi

Abstract

The surface of the outer membrane of Gram-negative bacteria is covered by a tightly packed layer of lipopolysaccharide molecules which provide a barrier against many toxic compounds and antibiotics. Lipopolysaccharide, synthesized in the cytoplasm, is assembled in the periplasmic leaflet of the inner membrane where the intermembrane Lpt system mediates its transport to the cell surface. The first step of lipopolysaccharide transport is its extraction from the outer leaflet of inner membrane powered by the atypical LptB2FGC ABC transporter. Here we review latest advances leading to understanding at molecular level how lipopolysaccharide is transported irreversibly to the outer membrane.

Citations

May 20, 2020·The Journal of Biological Chemistry·Chris WhitfieldSteven D Kelly
Jun 4, 2020·The Journal of Biological Chemistry·Jean-François ColletCamille V Goemans
Oct 21, 2020·Nature Ecology & Evolution·Najwa TaibSimonetta Gribaldo
Nov 2, 2019·Research in Microbiology·Grégory BoëlElie Dassa
May 9, 2021·Current Opinion in Structural Biology·Jani R BollaCarol V Robinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

ABC Transporters & Multidrug Resistance

ABC Transporters or ATP-Binding Cassette Transporters are responsible for pumping out antibiotics in the cell and can lead to multidrug resistance in bacteria. Discover the latest research on ABC Transporters & Multidrug Resistance here.