The LSM1-7 Complex Differentially Regulates Arabidopsis Tolerance to Abiotic Stress Conditions by Promoting Selective mRNA Decapping

The Plant Cell
Carlos Perea-ResaJulio Salinas

Abstract

In eukaryotes, the decapping machinery is highly conserved and plays an essential role in controlling mRNA stability, a key step in the regulation of gene expression. Yet, the role of mRNA decapping in shaping gene expression profiles in response to environmental cues and the operating molecular mechanisms are poorly understood. Here, we provide genetic and molecular evidence that a component of the decapping machinery, the LSM1-7 complex, plays a critical role in plant tolerance to abiotic stresses. Our results demonstrate that, depending on the stress, the complex from Arabidopsis thaliana interacts with different selected stress-inducible transcripts targeting them for decapping and subsequent degradation. This interaction ensures the correct turnover of the target transcripts and, consequently, the appropriate patterns of downstream stress-responsive gene expression that are required for plant adaptation. Remarkably, among the selected target transcripts of the LSM1-7 complex are those encoding NCED3 and NCED5, two key enzymes in abscisic acid (ABA) biosynthesis. We demonstrate that the complex modulates ABA levels in Arabidopsis exposed to cold and high salt by differentially controlling NCED3 and NCED5 mRNA turnover, whic...Continue Reading

Citations

Sep 30, 2016·Cellular and Molecular Life Sciences : CMLS·Dorota Kawa, Christa Testerink
May 10, 2017·Nucleic Acids Research·Cristian Carrasco-LópezJulio Salinas
May 17, 2019·Plant & Cell Physiology·Akihiro MatsuiMotoaki Seki
Feb 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Reed S SorensonLeslie E Sieburth
Nov 23, 2018·International Journal of Molecular Sciences·Yanlin MaYi Yang
Jan 8, 2019·F1000Research·Leslie E Sieburth, Jessica N Vincent
Jun 3, 2020·Nature Plants·Thanin ChantarachotJulia Bailey-Serres
Mar 30, 2018·Frontiers in Plant Science·Izabela WawerJoanna Kufel
Feb 16, 2017·Journal of Plant Research·Masayuki TsuzukiAtsushi Takeda
Mar 16, 2019·Frontiers in Plant Science·Rafael CataláJulio Salinas

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