The Lund concept for severe traumatic brain injury

The Cochrane Database of Systematic Reviews
Dario Muzevic, Bruno Splavski

Abstract

Severe traumatic brain injury is a significant cause of morbidity and mortality. Treatment strategies in management of such injuries are directed to the prevention of secondary brain ischaemia, as a consequence of disturbed post-traumatic cerebral blood flow. They are usually concerned with avoiding high intracranial pressure (ICP) or adequate cerebral perfusion pressure (CPP). An alternative to this conventional treatment is the Lund concept, which emphasises a reduction in microvascular pressures. To assess the role of the Lund concept versus other treatment modalities such as ICP-targeted therapy, CPP-targeted therapy or other possible treatment strategies in the management of severe traumatic brain injury. We searched the Cochrane Injuries Group's Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL; Issue 10, 2013), MEDLINE (OvidSP), EMBASE (OvidSP), CINAHL Plus (EBSCO Host), ISI Web of Science (SCI-EXPANDED and CPCI-S) and trials registries. We searched the reference lists of relevant studies and published reviews found with our search. The most recent search was 5 November 2013. Randomised controlled trials (RCTs, level 1 evidence) exploring the efficacy of the Lund concept in the treatment of tr...Continue Reading

References

Jul 13, 1974·Lancet·G Teasdale, B Jennett
Dec 1, 1995·Journal of Neurosurgery·M J RosnerA H Johnson
Feb 1, 1993·The Journal of Trauma·R M ChesnutM A Foulkes
Aug 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·Laurence T Dunn
Sep 27, 2003·Epilepsia·John Bruns, W Allen Hauser

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Citations

Mar 1, 2019·Medical Sciences : Open Access Journal·Reto A Stocker
Nov 22, 2019·The Cochrane Database of Systematic Reviews·Carlos Martín-SaboridoFernando G Baccaro
Jul 27, 2021·Frontiers in Veterinary Science·Armi Pigott, Elke Rudloff

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