The lung mast cell: its physiology and potential relevance to defense of the lung

Environmental Health Perspectives
S I Wasserman

Abstract

The mast cell, located at mucosal surfaces and surrounding venules, is uniquely positioned to respond rapidly to insults to the host by mediating the development of a wide-ranging inflammatory response. Activaton of the mast cell releases preformed granule-associated chemical mediators and generates de novo biologically active materials. The properties of the mast cell mediators permit development of both acute and prolonged inflammatory responses. the immediate response is characterized by edema and the delayed response by leukocyte infiltration and vascular damage. the mast cell mediators responsible for these inflammatory events are characterized functionally. The vasoactive/smooth muscle reactive mediators include preformed histamine and serotonin and newly-generated platelet activating factor, slow reacting substance of anaphylaxis and prostaglandins. Chemotactic mediators include eosinophil-selective ECF-A and ECF-oligopeptides, neutrophil-selective NCF, and lipid chemotactic mediators with broad specificity. These factors induce directed migration and localization of leukocytes. The mast cell releases the structural proteoglycan, heparin, which is anticoagulant and inhibits complement. Released mast cell enzymes include ...Continue Reading

References

Dec 1, 1975·The Journal of Experimental Medicine·R A ClarkA P Kaplan
May 1, 1976·The Journal of Clinical Investigation·L A KaterK F Austen
Jul 1, 1978·The Journal of Investigative Dermatology·B Uvnäs
Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter
Oct 1, 1976·Archives of Biochemistry and Biophysics·A L Oronsky, C W Buermann
Apr 1, 1975·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J A Kiernan
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E J Goetzl, K F Austen
Dec 1, 1973·Agents and Actions·B B Vargaftig
Nov 1, 1974·The Journal of Experimental Medicine·R A LewisK F Austen
Apr 21, 1972·Nature·J W BlackE M Parsons
Jul 1, 1973·The Journal of Allergy and Clinical Immunology·J DolovichJ Bienenstock
Oct 1, 1967·Archives of Dermatology·H Selye
Nov 1, 1953·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G GOMORI

❮ Previous
Next ❯

Citations

Jul 1, 1984·Thorax·M M WagnerJ C Wagner
Jan 1, 1985·Chest·M Kaliner
Mar 13, 2002·American Journal of Clinical Pathology·Sergio VidalBernd W Scheithauer
Jun 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·A I StrukovB A Kudriashov
Sep 15, 1985·Biochemical Pharmacology·T B CasaleM Kaliner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

© 2021 Meta ULC. All rights reserved