PMID: 7030457Dec 21, 1981Paper

The luteinizing hormone releasing hormone (LHRH) neuronal networks of the guinea pig brain. III. The regulation of cyclic gonadotropin secretion

Brain Research
L C Krey, A J Silverman

Abstract

The effects of selected CNS lesions on the ovulatory cycle as well as the distribution of LHRH terminals in the median eminence of the female guinea pig were examined. Radiofrequency lesions were placed in the medial preoptic area (MPOA) or suprachiasmatic nucleus (SCN). Animals were studied for varying lengths of time (1-5 months) following lesion placement. The occurrence of at least two ovulatory cycles was determined by cyclicity in vaginal opening, the presence of viable corpora lutea and measurements of luteal phase elevations in serum progesterone. The distribution of LHRH immunoreactivity was determined by immunocytochemical procedures on Bouin's fixed, paraffin-embedded brain sections. Lesions of the MPOA or SCN resulted in different degrees of loss of LHRH fibers in the zona externa of the ventral and lateral aspects of the infundibular stalk as well as complete loss of terminals throughout the zona interna. Despite depletion of LHRH fibers, all animals with SCN (n = 8) and the majority with MPOA (4/6) lesions showed regular ovulatory cycles. Two females with MPOA lesions presented two different anovulatory syndromes. Anovulation appeared unrelated to the size or site of the lesions or in the degree of depletion of LH...Continue Reading

References

Sep 5, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K Brown-GrantM C Sood
Sep 5, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K Brown-Grant, G Raisman
Apr 1, 1977·Brain Research·J Leonardelli, P Poulain
Jan 1, 1976·Acta Anatomica·L Barry, M P Dubois
May 15, 1980·The Journal of Comparative Neurology·M Schwanzel-Fukuda, A J Silverman
May 1, 1980·Brain Research Bulletin·C H Anderson, C L Shen

❮ Previous
Next ❯

Citations

Jan 1, 1986·Neuroscience and Biobehavioral Reviews·E M Kostarczyk
Jan 1, 1985·Neurochemistry International·P Robel, E E Baulieu
Apr 1, 1984·Brain Research Bulletin·M J KellyR L Eskay
Dec 31, 1987·Hearing Research·G R LaugelJ W Wright
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·E E Baulieu, P Robel
Apr 20, 2000·Neuroscience Research·K TsutsuiM Takase
Jan 6, 2000·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·K TsutsuiR W Lea
Sep 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J L CarreH H Floch
Jan 1, 1982·Scandinavian Journal of Psychology·T Archer
Jun 1, 1985·British Journal of Clinical Pharmacology·P J CowenL E Braddock
Jul 8, 1993·The Journal of Comparative Neurology·K L Buchanan, S M Yellon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.