Jan 15, 2015

The LUX Score: A Metric for Lipidome Homology

BioRxiv : the Preprint Server for Biology
Chakravarthy MarellaDominik Schwudke


Motivation We propose a method for estimating lipidome homologies analogous to the ones used in sequence analysis and phylogenetics. Results Algorithms were developed to quantify the structural similarity between lipids and to compute chemical space models of sets of lipid structures and lipidomes. When all lipid molecules of the LIPIDMAPS structure database were mapped in such a chemical space, they automatically formed clusters corresponding to conventional chemical families. Homologies between the lipidomes of four yeast strains based on our LUX score reflected the genetic relationship, although the score is based solely on lipid structures. Source code Availability [www.lux.fz-borstel.de][1] [1]: http://www.lux.fz-borstel.de

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Mentioned in this Paper

lipid structure
Anatomical Space Structure
Sequence Analysis
Lipids Profile Test
Lipids Measurement

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