The lymph node at a glance - how spatial organization optimizes the immune response.

Journal of Cell Science
Spencer M GrantAndrea J Radtke

Abstract

A hallmark of the mammalian immune system is its ability to respond efficiently to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore, a robust immune response requires the coordination of a diverse range of cells present at low frequencies within the host. This problem is solved, in part, by concentrating antigens, antigen-presenting cells and antigen-responsive cells in lymph nodes (LNs). Beyond housing these cell types in one location, LNs are highly organized structures consisting of pre-positioned cells within well-defined microanatomical niches. In this Cell Science at a Glance article and accompanying poster, we outline the key cellular populations and components of the LN microenvironment that are present at steady state and chronicle the dynamic changes in these elements following an immune response. This review highlights the LN as a staging ground for both innate and adaptive immune responses, while providing an elegant example of how structure informs function.

References

May 1, 1974·The Journal of Experimental Medicine·P B Carter, F M Collins
Jul 1, 1984·The American Journal of Anatomy·J G TewA K Szakal
Oct 24, 2000·Immunological Reviews·J G CysterV N Ngo
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Meenakshi P RoyEugene C Butcher
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth IngulliMarc K Jenkins
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter AichelePeter Seiler
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V T MARCHESI, J L GOWANS
Dec 12, 2003·Nature Reviews. Immunology·Ulrich H von Andrian, Thorsten R Mempel
Aug 10, 2004·Nature Immunology·Christopher D C AllenJason G Cyster
Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Dec 23, 2006·Science·Christopher D C AllenJason G Cyster
May 29, 2007·Nature Immunology·Nicolas FazilleauMichael G McHeyzer-Williams
Aug 29, 2007·Immunity·Christopher D C AllenJason G Cyster
Sep 26, 2007·Nature Immunology·Alexander LinkSanjiv A Luther
Aug 23, 2008·Immunity·Tatyana ChtanovaEllen A Robey
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoya KatakaiAkira Shimizu
Jun 10, 2009·The Journal of Experimental Medicine·Kazuhiro SuzukiJason G Cyster
Aug 1, 2009·Nature Reviews. Immunology·Scott N Mueller, Ronald N Germain
Jul 14, 2010·Immunity·David R FooksmanDimitris Skokos
Jul 26, 2011·Nature Medicine·Michelle A LintermanCarola G Vinuesa
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ivonne WollenbergLuis Graca
Jan 10, 2012·Annual Review of Immunology·Gabriel D Victora, Michel C Nussenzweig
Apr 11, 2012·Journal of Innate Immunity·Elizabeth E Gray, Jason G Cyster
Jun 30, 2012·Science·Ronald N GermainMichael D Cahalan
Sep 29, 2012·Nature Reviews. Immunology·Jean-Philippe GirardReinhold Förster
Dec 12, 2012·Annual Review of Immunology·Scott N MuellerWilliam R Heath

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Citations

Jun 18, 2020·Cancers·Elaheh Hashemi, Subramaniam Malarkannan
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Apr 20, 2021·Annual Review of Biomedical Engineering·Jennifer H HammelRebecca R Pompano
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