The dog infected with Brugia pahangi is an excellent model for studying the clinical and immunological pathogenesis of lymphatic filarial infection and disease. Dogs demonstrated a range of clinical changes including varying levels of microfilaraemia, episodic lymphadenopathy, lymphangitis, and limb oedema similar to the clinical spectrum reported in man. Histologically, tissues from parasite-infected dogs were characterized by fibrosis of the lymph nodes and their afferent and efferent lymphatic ducts in the infected limbs. Some nodes were atrophied while others were characterized by reactive hyperplasia. Duct walls of some afferent lymphatics were thickened with a mononuclear inflammatory infiltrate. Parasite antigen deposition was detected in the subcapsular sinuses and middle of germinal centres of infected popliteal lymph nodes, using an immunohistochemical technique.
The effect of Streptococcus on the persistence of Brugia malayi and on the production of elephantiasis in cats
Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production
Clinical and xeroradiographic lymphangiography studies of acute and chronic Brugia pahangi infections in dogs
Brugia pahangi: infections and their effect on the lymphatic system of Mongolian jirds (Meriones unguiculatus)
A chronological study of the histopathology of filarial disease in cats and dogs caused by Brugia pahangi (Buckley and Edeson, 1956)
A description of adult Wuchereria bancrofti (rural strain) from an experimental infection in the long-tailed macaque, Macaca fascicularis (sny. M. irus)
The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory
Inflammatory cytokines following diethylcarbamazine (DEC) treatment of different clinical groups in lymphatic filariasis
A novel gene from Brugia sp. that encodes a cytotoxic fatty acid binding protein allergen recognized by canine monoclonal IgE and serum IgE from infected dogs
The histopathology of bancroftian filariasis revisited: the role of the adult worm in the lymphatic-vessel disease
Bancroftian filariasis in children and adolescents: clinical-pathological observations in 22 cases from an endemic area
Occurrence of filaria in domestic dogs of Samburu pastoralists in Northern Kenya and its associations with canine distemper
Brugia pahangi: immunization with early L3 ES alters parasite migration, and reduces microfilaremia and lymphatic lesion formation in gerbils (Meriones unguiculatus)
Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis.
Seasonal distribution and environmental parameters associated with Brugia pahangi and Dirofilaria immitis in naturally infected dogs in Bangkok and vicinity, Thailand.
CSF & Lymphatic System
This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.