The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments.

The Journal of Biological Chemistry
Lin FengJunjie Chen

Abstract

BRCC36 is a member of the JAMM/MPN(+) family of zinc metalloproteases that specifically cleaves Lys 63-linked polyubiquitin chains in vitro. We and others showed previously that BRCC36 is a component of the BRCA1-A complex, which consists of RAP80, CCDC98/ABRAXAS, BRCC45/BRE, MERIT40/NBA1, BRCC36, and BRCA1. This complex participates in the regulation of BRCA1 localization in response to DNA damage. Here we provide evidence indicating that BRCC36 regulates the abundance of Lys(63)-linked ubiquitin chains at chromatin and that one of its substrates is diubiquitinated histone H2A. Moreover, besides interacting with CCDC98 within the BRCA1-A complex, BRCC36 also associates with another protein KIAA0157, which shares significant sequence homology with CCDC98. Interestingly, although CCDC98 functions as an adaptor of BRCC36 and regulates BRCC36 activity in the nucleus, KIAA0157 mainly localizes in cytosol and activates BRCC36 in the cytoplasm. Moreover, these two complexes appear to exist in fine balance in vivo because reduction of KIAA0157 expression led to an increase of the BRCA1-A complex in the nucleus. Together, these results suggest that scaffold proteins not only participate in the regulation of BRCC36 activity but also det...Continue Reading

References

Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Jun 25, 2002·The Journal of Biological Chemistry·Zhijiang YanAnton M Jetten
Jan 23, 2004·PLoS Biology·Xavier I AmbroggioRaymond J Deshaies
Aug 18, 2004·The Journal of Cell Biology·John McCulloughSylvie Urbé
Aug 3, 2005·Nature Reviews. Molecular Cell Biology·Rebecca L WelchmanR John Mayer
Dec 6, 2005·Cell·Sebastian M B NijmanRené Bernards
Sep 26, 2006·Trends in Cell Biology·Michael J Clague, Sylvie Urbé
Feb 17, 2007·Current Opinion in Cell Biology·Vladimir Kirkin, Ivan Dikic
May 26, 2007·Science·Bijan SobhianRoger A Greenberg
Jul 24, 2007·Nature Structural & Molecular Biology·Hongtae KimJunjie Chen
Nov 6, 2007·Current Biology : CB·Francesco NicassioElisabetta Citterio
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bin Wang, Stephen J Elledge
Mar 6, 2009·Genes & Development·Genze ShaoRoger A Greenberg
Mar 6, 2009·Genes & Development·Lin FengJunjie Chen
May 20, 2009·Molecular Cell·Vladimir KirkinIvan Dikic
Jun 6, 2009·Annual Review of Biochemistry·Francisca E Reyes-TurcuKeith D Wilkinson
Jul 25, 2009·Nature Reviews. Molecular Cell Biology·David KomanderSylvie Urbé
Dec 25, 2009·The Journal of Biological Chemistry·Eric M CooperRobert E Cohen

❮ Previous
Next ❯

Citations

Sep 5, 2013·Nature Reviews. Molecular Cell Biology·Stephanie Panier, Daniel Durocher
Jan 24, 2012·Nature Structural & Molecular Biology·Lin Feng, Junjie Chen
Oct 15, 2011·Oncogene·J M FraileC López-Otín
Feb 22, 2011·The Journal of Biological Chemistry·Kara A Coleman, Roger A Greenberg
Sep 10, 2013·Nucleic Acids Research·Andreas KakarougkasPenny A Jeggo
Mar 23, 2013·Orphanet Journal of Rare Diseases·Tara K SigdelGary K Steinberg
Mar 1, 2012·Cell & Bioscience·Bin Wang
Mar 19, 2013·Oncogene·H R Stone, J R Morris
May 17, 2011·FEBS Letters·Tomohiko OhtaWenwen Wu
May 31, 2011·FEBS Letters·Roger A Greenberg
Jun 20, 2012·Essays in Biochemistry·Melanie Neutzner, Albert Neutzner
Oct 1, 2013·Cell Reports·Hui ZhengRoger A Greenberg
Sep 15, 2012·Biochimica Et Biophysica Acta·Camilla T AmbiveroAntonis S Zervos
May 21, 2011·American Journal of Human Genetics·Snaigune MiskinyteElisabeth Tournier-Lasserve
Jul 5, 2016·Frontiers in Genetics·Shane M Harding, Roger A Greenberg
Jun 22, 2016·Acta Biochimica Et Biophysica Sinica·Joonyoung HerHongtae Kim
Oct 27, 2010·FEBS Letters·Boyko S AtanassovSharon Y Dent
Dec 24, 2016·Cell Reports·Otto J P KyrieleisStephen J Smerdon
Oct 7, 2014·Nature Communications·Jianhong ZhangXiaoming Yang
May 10, 2017·Journal of Cell Science·Pawel Leznicki, Yogesh Kulathu
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yu-Che Cheng, Sheau-Yann Shieh
Jul 29, 2018·Journal of Cellular and Molecular Medicine·Kaimin GuoZhenmin Lei
Dec 9, 2015·Molecular and Cellular Biology·Younghoon Kee, Tony T Huang
Feb 27, 2016·F1000Research·Erin S Coyne, Simon S Wing
Jun 6, 2019·Critical Reviews in Biochemistry and Molecular Biology·Jae Jin KimKyle M Miller
Jun 12, 2016·The Journal of Biological Chemistry·Hoi-Man NgMichael S Y Huen
Feb 8, 2020·Genes & Development·Kameron Azarm, Susan Smith
Sep 6, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mohit SinghUmesh C S Yadav
Jan 26, 2020·Nature Communications·Sreyoshi MitraLars E T Jansen
Aug 1, 2013·Physiological Reviews·Michael J ClagueSylvie Urbé
May 15, 2015·Oncotarget·Rongbin WeiShangfeng Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.