The lysate from bovine erythrocytes infected with Babesia bovis. Analysis of antigens and a report on their immunogenicity when polymerized with glutaraldehyde

Zeitschrift Für Parasitenkunde
B V GoodgerD J Waltisbuhl

Abstract

A group of Babesia bovis antigens obtained by a lengthy biochemical procedure involving disruption of infected erythrocytes has previously been shown to be highly protective. This study shows that these antigens can be found in a simple lysate of infected erythrocytes. The antigens have been characterized by gel filtration and nitrocellulose transfer and consist of a wide spectrum of molecular sizes. Some of the antigens exist in complex form and are easily dissociated. The lysate was polymerized with glutaraldehyde and injected per se into four splenectomized calves. All the calves produced antibody to B. bovis but did not produce erythrocytic isoantibodies. The vaccinated calves and a control group of four splenectomized calves were challenged with virulent B. bovis. Statistically, the vaccinated group differed significantly in parasitaemia, temperature change and pathophysiological parameters from the control group. All of the control group died whereas two of the vaccinated group survived infection.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Feb 16, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·M W Rampling, P J Gaffney
Oct 24, 1968·Analytical Biochemistry·J Margolis, K G Kenrick
Apr 1, 1967·Experimental Parasitology·D F Mahoney
Jan 1, 1982·Analytical Biochemistry·R HawkesJ Gordon

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Citations

Jan 1, 1987·Parasitology Research·D J WaltisbuhlD F Mahoney
Mar 1, 1996·Veterinary Parasitology·A el-GhayshA M Nassar
Jan 1, 1987·Veterinary Immunology and Immunopathology·B V GoodgerM A Commins

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