The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models

Frontiers in Immunology
Cecilia HagertRikard Holmdahl

Abstract

The injection of mannan into mice can result in the development of psoriasis (Ps) and psoriatic arthritis (PsA), whereas co-injection with antibodies toward collagen type II leads to a chronic rheumatoid-like arthritis. The critical event in all these diseases is mannan-mediated activation of macrophages, causing more severe disease if the macrophages are deficient in neutrophil cytosolic factor 1 (Ncf1), i.e., lack the capacity to make a reactive oxygen species (ROS) burst. In this study, we investigated the role of one of the receptors binding mannan; the macrophage mannose receptor (MR, CD206). MR is a C-type lectin present on myeloid cells and lymphatics. We found that mice deficient in MR expression had more severe mannan-induced Ps, PsA as well as rheumatoid-like arthritis. Interestingly, the MR-mediated protection was partly lost in Ncf1 mutated mice and was associated with an type 2 macrophage expansion. In conclusion, these results show that MR protects against a pathogenic inflammatory macrophage response induced by mannan and is associated with induction of ROS.

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Citations

Feb 4, 2019·Clinical and Experimental Immunology·C HagertR Holmdahl
Jul 3, 2019·International Journal of Molecular Sciences·Tatiana A KorolenkoVaclav Vetvicka
Jul 28, 2020·Scientific Reports·Pia SvendsenSøren K Moestrup
Apr 10, 2019·Journal of Leukocyte Biology·Ce TangYoichiro Iwakura
Jan 22, 2021·Autoimmunity Reviews·Jeffrey M A van der KrogtSander W Tas

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Methods Mentioned

BETA
biopsies
Genotyping

Software Mentioned

GraphPad Prism
Living Image
FlowJo

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