The macular hole: histopathologic studies

Archives of Ophthalmology
W Richard Green

Abstract

To delineate the light and electron microscopic features of tissue removed at the time of macular hole surgery. The ocular fluid specimens were concentrated using Millipore filters and stained with a modified Papanicolaou and the periodic acid-Schiff stains in 697 cases. In 92 cases, surgically isolated tissue was processed and examined by electron microscopy. The findings in the specimens studied by the Millipore filter technique included vitreous strands; cellular fragments in 108 cases (13.3%); fibrocellular fragments in 75 (9.2%); and fragments of internal limiting lamina (ILL) of the retina in 104 (12.8%). Findings in the 92 specimens with tissue studied by electron microscopy included native vitreous collagen in 48 cases (52.2%); new collagen in 6 (6.5%); native and new collagen in 1 (1.2%); ILL of the retina in 54 (58.7%); and a variety of cells in 22.5% of cases, including fibrocytes, myofibrocytes, fibrous astrocytes with and without myoblastic features, Mueller cells, retinal pigment epithelium with and without myoblastic features, and inflammatory cells. The organization of the tissue elements included a cellular layer along one surface of a layer of cortical vitreous in 18 cases, cortical vitreous along the inner su...Continue Reading

Citations

Aug 4, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Aman ChandraDavid Yorston
Nov 28, 2017·Clinical Proteomics·Pingbo ZhangSharon D Solomon
Apr 15, 2018·Stem Cell Research & Therapy·Feng ZhangYan He
Jan 7, 2009·International Ophthalmology Clinics·Marena PatronasEdward A Ryan
May 9, 2012·International Ophthalmology·A J SinghW H Woon
Jan 16, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·R G SchumannC Haritoglou
Jun 24, 2008·Survey of Ophthalmology·Ehab Abdelkader, Noemi Lois

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