The Mad side of the Max network: antagonizing the function of Myc and more

Current Topics in Microbiology and Immunology
Sabine Rottmann, Bernhard Lüscher

Abstract

A significant body of evidence has been accumulated that demonstrates decisive roles of members of the Myc/Max/Mad network in the control of various aspects of cell behavior, including proliferation, differentiation, and apoptosis. The components of this network serve as transcriptional regulators. Mad family members, including Mad1, Mxi1, Mad3, Mad4, Mnt, and Mga, function in part as antagonists of Myc oncoproteins. At the molecular level this antagonism is reflected by the different cofactor/chromatin remodeling complexes that are recruited by Myc and Mad family members. One important function of the latter is their ability to repress gene transcription. In this review we summarize the current view of how this repression is achieved and what the consequences of Mad action are for cell behavior. In addition, we point out some of the many aspects that have not been clarified and thus leave us with a rather incomplete picture of the functions, both molecular and at the cellular level, of Mad family members.

Citations

Nov 14, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabine RottmannBernhard Lüscher
Jun 27, 2012·Journal of Molecular Recognition : JMR·Marie-Eve BeaulieuPierre Lavigne
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·A OrianR N Eisenman
Sep 26, 2007·Molecular and Cellular Biology·Jun-Soo YunElva Díaz
Jun 28, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaotian WangJiu-Cun Wang
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Barbara MarinariAntonio Costanzo
May 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jidong ZhuJunying Yuan
Aug 19, 2007·The FEBS Journal·Claire Dugast-DarzacqNicole B Schreiber-Agus
Jan 10, 2012·Gene·Bernhard Lüscher, Jörg Vervoorts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis