The magnitude and colour of noise in genetic negative feedback systems.

Nucleic Acids Research
Margaritis Voliotis, Clive G Bowsher

Abstract

The comparative ability of transcriptional and small RNA-mediated negative feedback to control fluctuations or 'noise' in gene expression remains unexplored. Both autoregulatory mechanisms usually suppress the average (mean) of the protein level and its variability across cells. The variance of the number of proteins per molecule of mean expression is also typically reduced compared with the unregulated system, but is almost never below the value of one. This relative variance often substantially exceeds a recently obtained, theoretical lower limit for biochemical feedback systems. Adding the transcriptional or small RNA-mediated control has different effects. Transcriptional autorepression robustly reduces both the relative variance and persistence (lifetime) of fluctuations. Both benefits combine to reduce noise in downstream gene expression. Autorepression via small RNA can achieve more extreme noise reduction and typically has less effect on the mean expression level. However, it is often more costly to implement and is more sensitive to rate parameters. Theoretical lower limits on the relative variance are known to decrease slowly as a measure of the cost per molecule of mean expression increases. However, the proportional...Continue Reading

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Citations

Dec 7, 2013·BMC Genomics·Philipp ThomasRamon Grima
Apr 5, 2013·PLoS Computational Biology·Clive G BowsherPeter S Swain
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Margaritis VoliotisClive G Bowsher
Dec 17, 2014·Biochimica Et Biophysica Acta·Yan ZhangZhi-Hu Zhao
Apr 17, 2014·ACS Synthetic Biology·Diego A OyarzúnGuy-Bart V Stan
Sep 10, 2016·Scientific Reports·Ricardo C H Del RosarioBaltazar D Aguda
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Sep 28, 2016·Bioinspiration & Biomimetics·K C HeydeW C Ruder
Aug 5, 2020·Molecular and Cellular Endocrinology·Robert Jp PopeCraig A McArdle
Jul 29, 2021·PLoS Computational Biology·Saurabh ModiAbhyudai Singh
May 8, 2018·ACS Synthetic Biology·Chelsea Y HuJulius B Lucks

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