The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database

Therapeutic Advances in Gastroenterology
Yuqiang LiWenxue Liu

Abstract

There is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival. Data from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989-1990 and 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank test, Cox regression model and propensity score matching. The Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989-1990 to 2009-2010. The 95% confidence intervals (CIs) for surgical resection in 2009-2010 were narrower than those in 1989-1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC (p = 0.303) and RC (p = 0.660). Chemotherapy had a significant association with OS of all colorectal cancer (CRC) patients (p =...Continue Reading

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Citations

Jan 15, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dan WangYuqiang Li
Aug 13, 2020·Therapeutic Advances in Gastroenterology·Kangtao WangFengbo Tan
Dec 11, 2020·Gastroenterology Research and Practice·Yuqiang LiHong Zhu
Oct 20, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David MalkaFrédéric Bibeau
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Yuqiang LiCenap Güngör

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS
SEER

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