The maintenance of strain structure in populations of recombining infectious agents

Nature Medicine
Sunetra GuptaR M Anderson

Abstract

Using mathematical models that combine population genetic and epidemiological processes, we resolve the paradox that many important pathogens appear to persist as discrete strains despite the constant exchange of genetic material. We show that dominant polymorphic determinants (that is, those that elicit the most effective immune responses) will be organized into nonoverlapping combinations as a result of selection by the host immune system, thereby defining a set of discrete independently transmitted strains. By analysing 222 isolates of Neisseria meningitidis, we show that two highly polymorphic epitopes of the outer membrane protein PorA exist in nonoverlapping combinations as predicted by this general framework. The model indicates that dominant polymorphic determinants will be in linkage disequilibrium, despite frequent genetic exchange, even though they may be encoded by several unlinked genes. This suggests that the detection of nonrandom associations between epitope regions can be employed as a novel strategem for identifying dominant polymorphic antigens.

References

Aug 11, 1990·Lancet·W F CarmanH C Thomas
Jan 3, 1991·Nature·J M SmithB G Spratt
Oct 1, 1989·Experimental Parasitology·D Walliker
Dec 1, 1987·Epidemiology and Infection·K A CartwrightN D Noah
Nov 1, 1972·The Journal of Infectious Diseases·F A WyleJ P Lowenthal
Jan 1, 1993·Progress in Clinical Parasitology·T R JonesS L Hoffman
Mar 9, 1995·Nature·D L RobertsonB H Hahn
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J M SmithB G Spratt
Feb 1, 1996·Journal of Molecular Evolution·P L BollykyE C Holmes
Jan 1, 1994·Parasitology Today·S Gupta, K P Day

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Citations

Mar 18, 2005·Journal of Mathematical Biology·L J Abu-Raddad, N M Ferguson
Oct 16, 2012·Journal of Mathematical Biology·Bernard S Chan, Pei Yu
Dec 13, 2000·International Journal for Parasitology·R C Thompson
Jan 5, 2000·International Journal for Parasitology·U M MorganR C Thompson
Nov 9, 2000·Molecular and Biochemical Parasitology·J D SmithL H Miller
May 18, 2001·Molecular and Biochemical Parasitology·R H BinksD J Conway
Feb 19, 2002·Molecular and Biochemical Parasitology·Elizabeth V FowlerQin Cheng
Jul 28, 2004·Parasitology Today·I M Hastings, B Wedgwood-Oppenheim
Jul 28, 2004·Parasitology Today·U M MorganR C Thompson
Nov 11, 1999·Parasitology Today·S Gupta, R M Anderson
Apr 5, 2001·Trends in Microbiology·S Gupta, M C Maiden
Jun 8, 2001·Trends in Microbiology·B S Cooper
Mar 21, 1998·Nature Medicine·G A Targett
Apr 1, 1996·Nature Medicine·N B FreimerM Slatkin
Aug 9, 2006·Nature Reviews. Microbiology·Klaus KurtenbachNicholas H Ogden
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Caroline O BuckeeMartin C J Maiden
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Caroline O BuckeeSunetra Gupta
Nov 16, 2011·Genome Biology and Evolution·Weilong HaoDavid C Alexander
Apr 12, 2007·Journal of the Royal Society, Interface·Marc Lipsitch, Justin J O'Hagan
Mar 19, 1999·Proceedings. Biological Sciences·S GuptaC Newbold
Feb 13, 2002·Proceedings. Biological Sciences·M Gabriela M GomesD James Nokes
Feb 20, 2003·Proceedings. Biological Sciences·Alison P GalvaniNeil M Ferguson
Dec 14, 2004·Proceedings. Biological Sciences·Laith J Abu-Raddad, Neil M Ferguson
May 17, 2007·Proceedings. Biological Sciences·Caroline BuckeeSunetra Gupta
Oct 2, 2008·Proceedings. Biological Sciences·Caroline O BuckeeSunetra Gupta
Feb 5, 2010·Proceedings. Biological Sciences·Caroline O BuckeeKeith A Jolley
Dec 24, 2010·Proceedings. Biological Sciences·Ben Adams, Alice Carolyn McHardy
Jan 4, 2013·Proceedings. Biological Sciences·Erida GjiniChristina A Cobbold
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K Marsh, R W Snow
Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S Gupta, A Galvani
Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C C LordM E Woolhouse
Feb 6, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul S WikramaratnaSunetra Gupta
Jul 10, 1999·Immunological Reviews·D Wodarz, M A Nowak
May 17, 2011·Applied and Environmental Microbiology·Steven L FoleySteven C Ricke
Jan 18, 2005·Clinical Microbiology Reviews·Gunnar LindahlThomas Areschoug
Jun 28, 2013·Clinical and Vaccine Immunology : CVI·Jay LucidarmeRay Borrow
Aug 24, 2006·Infection and Immunity·Martin J CallaghanMartin C J Maiden
Aug 19, 2007·Infection and Immunity·Daniel N WolfeEric T Harvill
Oct 27, 2004·Infection and Immunity·Michelle L Gatton, Qin Cheng
Jun 17, 2008·Journal of Bacteriology·Anne M BuboltzEric T Harvill

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