The maize (Zea mays) desynaptic (dy) mutation defines a pathway for meiotic chromosome segregation, linking nuclear morphology, telomere distribution and synapsis

Journal of Cell Science
Shaun P Murphy, Hank W Bass

Abstract

Meiosis involves a dramatic reorganization of the genetic material, along with changes in the architecture of the nucleoplasm and cytoplasm. In the opisthokonts, nuclear envelope and meiotic chromosome behavior are coordinated by forces generated in the cytoplasm and transferred to the nucleus by the nuclear-envelope protein linkers SUN and KASH. During meiotic prophase I, the telomere bouquet arrangement has roles in interhomolog recognition, pairing, synapsis, interlock resolution and homologous chromosome recombination. The maize desynaptic (dy) mutant is defective in homologous chromosome synapsis, recombination, telomere-nuclear envelope interactions and chromosome segregation. A detailed three-dimensional cytological analysis of dy revealed telomere misplacement during the bouquet stage, synaptic irregularities, nuclear envelope distortion and chromosome bridges at anaphase I. Using linkage and B-A translocation mapping, we placed dy on the long arm of chromosome 3, genetic bin 3.06. SSR marker analysis narrowed the mapping interval to 9 cM. Candidate genes in this region include a PM3-type SUN domain protein, ZmSUN3. No obvious genetic lesions were found in the ZmSUN3 allele of dy, but a conspicuous splice variant, ZmSUN...Continue Reading

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Citations

May 30, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·F M BassiS F Kianian
Apr 1, 2016·Current Opinion in Cell Biology·Iris MeierAlecia Wagner
Nov 22, 2014·The Plant Journal : for Cell and Molecular Biology·Javier VarasSusan J Armstrong
May 18, 2013·Nucleus·Xiao Zhou, Iris Meier
Jan 18, 2013·Nucleus·Katja GraumannGeraint Parry
Mar 6, 2015·Journal of Experimental Botany·Xiao ZhouIris Meier
Apr 8, 2014·Current Opinion in Cell Biology·G W Gant Luxton, Daniel A Starr
Feb 23, 2017·Annual Review of Plant Biology·Iris MeierDavid E Evans
Mar 19, 2019·Nucleus·Monica PradilloKatja Graumann
Jun 27, 2020·Journal of Experimental Botany·Nadia Fernández-Jiménez, Mónica Pradillo
Jan 30, 2018·Frontiers in Cell and Developmental Biology·Xinhua ZengXiaohong Yan
Aug 1, 2018·Frontiers in Plant Science·Yazhong WangYan He
Mar 27, 2019·International Journal of Molecular Sciences·Kateřina PerničkováDavid Kopecký

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