The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Anneli M L EdströmOle E Sørensen

Abstract

One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of the semenogelins while the semenogelin holoproteins displayed no antibacterial activity. After ejaculation the semenogelin-derived peptides were fragmented to smaller and smaller fragments over time and thereby lost antibacterial activity. This paralleled the loss of antibacterial activity of whole seminal plasma both in vitro and after sexual intercourse. Moreover, the antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH. These data provide novel roles for the resolution of seminal clots and for the high zinc concentration in human seminal plasma.

References

Sep 1, 1976·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H SchiesslerH Fritz
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H Lilja, A Lundwall
Mar 21, 1991·Journal of Immunological Methods·R I LehrerP Eisenhauer
Jun 1, 1989·International Journal of Andrology·L WichmannP Tuohimaa
Nov 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·H Lilja, C B Laurell
Jan 1, 1974·Scandinavian Journal of Urology and Nephrology·P A Mårdh, S Colleen
Sep 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·H Lilja, C B Laurell
Aug 7, 1997·Journal of Immunological Methods·O SørensenN Borregaard
Sep 19, 2002·American Journal of Obstetrics and Gynecology·Erika V ValoreTomas Ganz
Nov 14, 2003·Biology of Reproduction·Frédéric BourgeonCharles Pineau
Nov 27, 2004·The Biochemical Journal·Magnus JonssonJohan Malm
Nov 8, 2005·Human Reproduction Update·S S Suarez, A A Pacey
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nitya VenkataramanAlexander M Cole
May 18, 2006·The FEBS Journal·Victoria RydengårdArtur Schmidtchen
Jul 28, 2007·Biochimica Et Biophysica Acta·Lukasz KacprzykArtur Schmidtchen

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Citations

Jun 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julie A MartelliniAlexander M Cole
Feb 26, 2010·Biological Chemistry·Georgia Sotiropoulou, Georgios Pampalakis
Dec 21, 2018·Andrologia·Ruben D MotrichVirginia E Rivero
Oct 31, 2012·Molecular Reproduction and Development·Brooke A Laflamme, Mariana F Wolfner
May 28, 2014·American Journal of Reproductive Immunology : AJRI·Matthew R KovakAlan B Diekman
Aug 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·M Veronica Clavijo JordanA Dean Sherry
Sep 22, 2019·International Journal of Molecular Sciences·Miyuki ShindoNatsuko Kawano
Jul 14, 2020·The Journal of Obstetrics and Gynaecology Research·Joana RoloAna Palmeira-de-Oliveira
Sep 13, 2017·Scientific Reports·Nishi GuptaSingh Rajender
Jan 23, 2018·Frontiers in Medicine·Louise C Kenny, Douglas B Kell
Jun 13, 2020·Biology of Reproduction·Prashanth Anamthathmakula, Wipawee Winuthayanon
Aug 12, 2014·Nature Reviews. Microbiology·Jan MünchFrank Kirchhoff
Mar 1, 2017·Cell Biology International·Amado A Quintar, Cristina A Maldonado
Oct 4, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masayori Hagimori
Nov 17, 2019·Nature Reviews. Urology·Signe AltmäeReet Mändar
Jan 8, 2013·Molecular Biology and Evolution·Zélia FerreiraBelen Hurle
Sep 14, 2019·Theriogenology·Marzena Mogielnicka-BrzozowskaWładysław Kordan
Feb 16, 2019·Biochemical and Biophysical Research Communications·Bhanu Pratap SinghMusti J Swamy
May 10, 2021·Cell Death Discovery·Oleg ShuvalovNikolai Barlev
Nov 3, 2021·Biopreservation and Biobanking·Samara Sandy Jerônimo MoreiraAlexandre Rodrigues Silva
Jan 5, 2011·Reproductive Biomedicine Online·Peng WangXinru Wang
Jan 18, 2011·Talanta·Masayori HagimoriYoshinori Tominaga

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