PMID: 9450339Feb 5, 1998Paper

The major elderberry (Sambucus nigra) fruit protein is a lectin derived from a truncated type 2 ribosome-inactivating protein

The Plant Journal : for Cell and Molecular Biology
E J Van DammeW J Peumans

Abstract

The major protein of elderberry (Sambucus nigra L.) fruits is a lectin, called Sambucus nigra agglutinin IVf or SNAIVf. This lectin is composed of subunits that strongly resemble the B chain of the type 2 ribosome-inactivating protein (RIP), called SNAVf, present in the same tissue. To corroborate the possible relationship between both proteins their corresponding cDNAs were cloned and compared. Alignment of the deduced amino acid sequences revealed that the cDNA encoding SNAIVf is almost identical to that of SNAVf except that its A chain is truncated. Northern blot analysis confirmed that the mRNA encoding SNAIVf is about 500 nucleotides shorter than the SNAVf mRNA. In addition, the occurrence of a truncated type 2 RIP gene was unambiguously demonstrated by the analysis of PCR amplified genomic sequences. These results not only demonstrate for the first time that a plant lectin is encoded by a truncated type 2 RIP gene but also address important questions with respect to the molecular evolution of RIP and lectins.

Citations

Dec 4, 2001·Biochimica Et Biophysica Acta·M Martínez-CruzF Córdoba
Feb 5, 2003·The International Journal of Biochemistry & Cell Biology·Fa-Jian HouWang-Yi Liu
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·M Angeles RojoTomás Girbés
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·Elvira González De Mejía, Valentin I Prisecaru
Apr 7, 2004·European Journal of Biochemistry·Frank VandenbusscheEls J M Van Damme
Jun 13, 2001·Biochemical and Biophysical Research Communications·L CandyP Rougé
May 27, 2015·Toxins·Joachim SchrotMatthias F Melzig
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Förster-WaldlE Jensen-Jarolim
Jun 24, 2009·Phytotherapy Research : PTR·J E VlachojannisS Chrubasik
Sep 29, 2004·Biochimica Et Biophysica Acta·M R Hartley, J M Lord
Feb 16, 2017·Phytotherapy Research : PTR·Randall S Porter, Robert F Bode

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