The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations.

Scientific Reports
Prajjval Pratap SinghGyaneshwer Chaubey

Abstract

With the growing evidence on the variable human susceptibility against COVID-19, it is evident that some genetic loci modulate the severity of the infection. Recent studies have identified several loci associated with greater severity. More recently, a study has identified a 50 kb genomic segment introgressed from Neanderthal adding a risk for COVID-19, and this genomic segment is present among 16% and 50% people of European and South Asian descent, respectively. Our studies on ACE2 identified a haplotype present among 20% and 60% of European and South Asian populations, respectively, which appears to be responsible for the low case fatality rate among South Asian populations. This result was also consistent with the real-time infection rate and case fatality rate among various states of India. We readdressed this issue using both of the contrasting datasets and compared them with the real-time infection rates and case fatality rate in India. We found that the polymorphism present in the 50 kb introgressed genomic segment (rs10490770) did not show any significant correlation with the infection and case fatality rate in India.

References

Oct 28, 2010·Molecular Biology and Evolution·Gyaneshwer ChaubeyToomas Kivisild
Oct 29, 2010·Nature·Gonçalo R AbecasisGil A McVean
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Nov 26, 2015·Legal Medicine·Gazi Nurun Nahar SultanaGyaneshwer Chaubey
Jun 16, 2017·Genome Biology·Gyaneshwer ChaubeyKumarasamy Thangaraj
Jan 23, 2018·Human Genetics·Rakesh TamangKumarasamy Thangaraj
Dec 12, 2018·American Journal of Human Genetics·Ajai K PathakRichard Villems
Mar 9, 2019·Scientific Reports·Kai TätteMait Metspalu
Mar 15, 2020·The Lancet. Respiratory Medicine·Lei FangMichael Roth
Apr 16, 2020·JAMA : the Journal of the American Medical Association·Clyde W Yancy
May 12, 2020·JAMA : the Journal of the American Medical Association·Monica Webb HooperEliseo J Pérez-Stable
May 14, 2020·Human Genomics·Krystal J Godri PollittVasilis Vasiliou
Jun 9, 2020·American Journal of Physiology. Cell Physiology·Keshav K SinghPrashanth Suravajhala
Jun 17, 2020·Critical Reviews in Food Science and Nutrition·Ricardo Wesley AlbercaMaria Notomi Sato
Jul 1, 2020·The Journal of Infectious Diseases·Ravina KullarTina Tan
Jan 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·B Brett FinlayTamara Giles-Vernick

❮ Previous
Next ❯

Citations

Oct 22, 2021·The Journal of Clinical Investigation·Vito Luigi ColonaGiuseppe Novelli

❮ Previous
Next ❯

Software Mentioned

Excel
Plink

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Lancet Infectious Diseases
Dimple D RajgorSwee Chye Quek
Epidemiology
Heath Kelly, Benjamin J Cowling
Archives of Iranian Medicine
Amir Almasi-HashianiMohammad Ali Mansournia
© 2021 Meta ULC. All rights reserved