The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice.

The Journal of Nutrition
Mousumi BoseChung S Yang

Abstract

In this study, we investigated the effects of the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), on high-fat-induced obesity, symptoms of the metabolic syndrome, and fatty liver in mice. In mice fed a high-fat diet (60% energy as fat), supplementation with dietary EGCG treatment (3.2 g/kg diet) for 16 wk reduced body weight (BW) gain, percent body fat, and visceral fat weight (P < 0.05) compared with mice without EGCG treatment. The BW decrease was associated with increased fecal lipids in the high-fat-fed groups (r(2) = 0.521; P < 0.05). EGCG treatment attenuated insulin resistance, plasma cholesterol, and monocyte chemoattractant protein concentrations in high-fat-fed mice (P < 0.05). EGCG treatment also decreased liver weight, liver triglycerides, and plasma alanine aminotransferase concentrations in high-fat-fed mice (P < 0.05). Histological analyses of liver samples revealed decreased lipid accumulation in hepatocytes in mice treated with EGCG compared with high-fat diet-fed mice without EGCG treatment. In another experiment, 3-mo-old high-fat-induced obese mice receiving short-term EGCG treatment (3.2 g/kg diet, 4 wk) had decreased mesenteric fat weight and blood glucose compared with high-fat-fed cont...Continue Reading

References

Mar 18, 1995·BMJ : British Medical Journal·K Imai, K Nakachi
Jul 1, 1993·The American Journal of Clinical Nutrition·M ZamboniO Bosello
Nov 6, 2001·The Journal of Nutrition·W RumplerK Hosoda
Jul 16, 2002·The Journal of Biological Chemistry·Mary E Waltner-LawDaryl K Granner
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T MuraseI Tokimitsu
Nov 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S Rössner
May 27, 2003·Diabetes Care·Kazuaki HosodaShigeru Yamamoto
Jul 23, 2003·The Journal of Nutritional Biochemistry·Daniel G RaederstorffPeter Weber
Oct 2, 2003·The Journal of Nutrition·Joshua D Lambert, Chung S Yang
Mar 10, 2004·The British Journal of Nutrition·Eva M R KovacsMargriet S Westerterp-Plantenga
May 29, 2004·The Journal of Biological Chemistry·Varman T SamuelGerald I Shulman
Nov 18, 2004·Angiology·S S DaskalopoulouM Elisaf
Jan 11, 2005·The American Journal of Clinical Nutrition·Tomonori NagaoIchiro Tokimitsu
Mar 2, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S KlausS Wolfram
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Farrell, Claire Z Larter
Feb 14, 2006·Molecular Nutrition & Food Research·Swen WolframFrank Thielecke
May 26, 2006·Journal of Lipid Research·Takahiro TsujitaJun Hiraki
Sep 8, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Barbara MlinarMarija Pfeifer
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Kristina M Utzschneider, Steven E Kahn
Sep 22, 2006·The Journal of Nutrition·Swen WolframPeter Weber
Jan 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·Maria A PotenzaMonica Montagnani

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Citations

Apr 23, 2010·Chemical & Pharmaceutical Bulletin·Hiroyuki TsutsumiTakashi Ishizu
May 22, 2010·European Journal of Oral Sciences·Tadashi NakanishiTakashi Matsuo
Aug 23, 2011·The Proceedings of the Nutrition Society·K P ConroyM Warnock
Jul 29, 2011·Annals of the New York Academy of Sciences·Myung-Sunny KimDae Young Kown
Jan 10, 2010·Food & Function·Min-Hsiung PanChi-Tang Ho
Jun 23, 2011·Diabetes/metabolism Research and Reviews·Theodoros Thomas, Andreas F H Pfeiffer
Jan 10, 2012·Nutrition Reviews·Christopher Masterjohn, Richard S Bruno
Aug 2, 2011·Chemical & Pharmaceutical Bulletin·Hiroyuki TsutsumiTakashi Ishizu
Jul 24, 2012·Chinese Journal of Integrative Medicine·Neeru VasudevaSurendra Kumar Sharma
Oct 6, 2012·Molecular Nutrition & Food Research·Sarah C ForesterJoshua D Lambert
Oct 20, 2012·Journal of the Science of Food and Agriculture·Noemi BoquéJ Alfredo Martínez
Nov 15, 2012·Oxidative Medicine and Cellular Longevity·I AndújarJ L Ríos
Nov 19, 2015·Molecular Nutrition & Food Research·Chung S YangYijun Wang
Apr 20, 2016·International Journal of Molecular Sciences·Mohammed Kawser HossainSsang-Goo Cho
Jul 26, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yashi MiXuebo Liu
Apr 3, 2018·Biological & Pharmaceutical Bulletin·Kensuke NakajimaHiroko Kariyazono
Apr 29, 2020·International Journal of Molecular Sciences·Marica MeroniPaola Dongiovanni
May 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Amy M KnabDavid C Nieman
Jun 12, 2010·Nutrition Reviews·Forrest H Nielsen
Sep 16, 2011·American Journal of Physiology. Endocrinology and Metabolism·Angélica Ruiz-RamírezMohammed El-Hafidi
Mar 21, 2012·Journal of the Science of Food and Agriculture·Juan P Barrios-RamosMaria E Jaramillo-Flores

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