Feb 1, 1995

The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Diana M Juriloff, D G Mah

Abstract

Cleft lip with or without cleft palate, CL(P), a common human birth defect, has a genetically complex etiology. An animal model with a similarly complex genetic basis is established in the A/WySn mouse strain, in which 20% of newborns have CL(P). Using a newly created congenic strain, AEJ.A, and SSLP markers, we have mapped a major CL(P)-causing gene derived from the A/WySn strain. This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus.

Mentioned in this Paper

CRLF1
Retinoic acid receptor alpha
Cleft Palate, Isolated
RARA wt Allele
Genetic Markers
Etiology
Genome Mapping
Cleft Lip With or Without Cleft Palate
Chromosomes
Congenic Strain

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