The majority of patients with newly diagnosed juvenile idiopathic arthritis achieve a health-related quality of life that is similar to that of healthy peers: results of the German multicenter inception cohort (ICON)

Arthritis Research & Therapy
Miriam ListingKirsten Minden

Abstract

Achieving the best possible health-related quality of life (HRQoL) for a patient is an important treatment goal in juvenile idiopathic arthritis (JIA). We investigated the 36-month trajectories of HRQoL in children with JIA compared with healthy peers and identified the predictors of an unfavorable HRQoL. Patients with a recent JIA diagnosis were enrolled in the German inception cohort study ICON. As a peer group, friends of patients of the same age and sex were asked to cooperate. Children were prospectively followed and regularly questioned about their HRQoL using the Pediatric Quality of Life Inventory 4.0 (PedsQL). Disease activity was assessed by the clinical Juvenile Arthritis Disease Activity Score (cJADAS-10), and the burden of the child's chronic illness on their family was assessed by the Family Burden Questionnaire (FaBel). Linear mixed models were used to compare the HRQoL of the patients and their peers. Associations between the health status of a patient at enrollment and an unfavorable HRQoL (PedsQL total < 79.3) at their 3-year follow-up (FU) were analyzed by logistic regression. Data from 953 patients (median symptom duration 6 months, mean age 7.9 years) and 491 healthy peers (aged 8.4 years) were analyzed. Du...Continue Reading

References

Aug 1, 1991·Controlled Clinical Trials·M Bullinger, J Hasford
Apr 1, 1980·Medical Care·R E Stein, C K Riessman
Dec 1, 1994·Arthritis and Rheumatism·G SinghD P Goldsmith
Jul 1, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R Goodman
Sep 5, 2001·Psychotherapie, Psychosomatik, medizinische Psychologie·U Ravens-SiebererU Thyen
Mar 13, 2003·Arthritis and Rheumatism·Helen E FosterIan D Griffiths
Nov 18, 2003·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·James W VarniDouglas Skarr
Apr 4, 2006·Arthritis and Rheumatism·K L ShawJ E McDonagh
May 12, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Karine Toupin AprilCiarán M Duffy
Aug 1, 2006·Rheumatology·R Gutiérrez-SuárezUNKNOWN Pediatric Rheumatology International Trials Organisation (PRINTO)
Oct 30, 2007·Annals of the Rheumatic Diseases·S Magni-ManzoniA Ravelli
Jun 4, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Penney UptonChristine Eiser
Feb 28, 2009·Arthritis and Rheumatism·Michael SeidDaniel J Lovell
Jan 1, 1997·European Psychiatry : the Journal of the Association of European Psychiatrists·S SaxenaUNKNOWN WHOQOL Group
Jul 3, 2010·Arthritis Care & Research·Nicolino RupertoUNKNOWN Pediatric Rheumatology Collaborative Study Group (PRCSG)
May 12, 2011·Arthritis and Rheumatism·Ellen NordalUNKNOWN Nordic Study Group of Pediatric Rheumatology
Jun 21, 2011·Lancet·Berent PrakkenAlberto Martini
Dec 14, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gregor DueckersTim Niehues
Jan 11, 2012·Arthritis and Rheumatism·Alessandro ConsolaroUNKNOWN Paediatric Rheumatology International Trials Organization
Dec 22, 2012·Annals of the Rheumatic Diseases·Flora McErlaneUNKNOWN Childhood Arthritis Prospective Study (CAPS)
Apr 26, 2014·F1000prime Reports·Timothy Beukelman
Jun 22, 2014·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Thomas LampertUNKNOWN KiGGS Study Group
Jun 26, 2014·Annals of the Rheumatic Diseases·E H Pieter van Dijkhuizen, Nico M Wulffraat
Sep 4, 2015·The Journal of Rheumatology·Alysha J TaxterPamela F Weiss
Dec 15, 2015·Rheumatology·Alessandro Consolaro, Angelo Ravelli
Mar 21, 2017·Arthritis Care & Research·Kiem OenUNKNOWN the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators

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Citations

Mar 13, 2019·Musculoskeletal Care·Sirirat Charuvanij, Chollada Chaiyadech
May 16, 2019·Current Opinion in Rheumatology·Jaime GuzmanThomas Loughin
Jul 10, 2019·Arthritis Research & Therapy·Gabriella GiancaneAngelo Ravelli
Oct 22, 2019·Frontiers in Endocrinology·Jonna M E MännistöHanna Huopio
Jul 20, 2019·Pediatric Rheumatology Online Journal·Nentwich JuliaHofmann Christine
Jun 26, 2020·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Claudia SenglerKirsten Minden
Jan 29, 2022·Nature Reviews. Disease Primers·Alberto MartiniNicolino Ruperto

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Software Mentioned

cJADAS
SAS®
PedsQL

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