The malaria parasite Plasmodium falciparum: cell biological peculiarities and nutritional consequences.

Protoplasma
Stefan BaumeisterKlaus Lingelbach

Abstract

Apicomplexan parasites obligatorily invade and multiply within eukaryotic cells. Phylogenetically, they are related to a group of algae which, during their evolution, have acquired a secondary endosymbiont. This organelle, which in the parasite is called the apicoplast, is highly reduced compared to the endosymbionts of algae, but still contains many plant-specific biosynthetic pathways. The malaria parasite Plasmodium falciparum infects mammalian erythrocytes which are devoid of intracellular compartments and which largely lack biosynthetic pathways. Despite the limited resources of nutrition, the parasite grows and generates up to 32 merozoites which are the infectious stages of the complex life cycle. A large part of the intra-erythrocytic development takes place in the so-called parasitophorous vacuole, a compartment which forms an interface between the parasite and the cytoplasm of the host cell. In the course of parasite growth, the host cell undergoes dramatic alterations which on one hand contribute directly to the symptoms of severe malaria and which, on the other hand, are also required for parasite survival. Some of these alterations facilitate the acquisition of nutrients from the extracellular environment which are...Continue Reading

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Jul 13, 2011·Marine Drugs·Catherine Vonthron-SénécheauAnne-Marie Rusig
Jan 1, 2010·Malaria Research and Treatment·Gunanidhi DhangadamajhiManoranjan Ranjit
Jun 18, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Daniel Moog, Uwe G Maier
Jan 26, 2020·Nature Reviews. Microbiology·Joachim M MatzMichael J Blackman

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