The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

Molecular Biology and Evolution
Rowena E Martin, Kiaran Kirk

Abstract

The malaria parasite's chloroquine resistance transporter (CRT) is an integral membrane protein localized to the parasite's acidic digestive vacuole. The function of CRT is not known and the protein was originally described as a transporter simply because it possesses 10 transmembrane domains. In wild-type (chloroquine-sensitive) parasites, chloroquine accumulates to high concentrations within the digestive vacuole and it is through interactions in this compartment that it exerts its antimalarial effect. Mutations in CRT can cause a decreased intravacuolar concentration of chloroquine and thereby confer chloroquine resistance. However, the mechanism by which they do so is not understood. In this paper we present the results of a detailed bioinformatic analysis that reveals that CRT is a member of a previously undefined family of proteins, falling within the drug/metabolite transporter superfamily. Comparisons between CRT and other members of the superfamily provide insight into the possible role of the protein and into the significance of the mutations associated with the chloroquine resistance phenotype. The protein is predicted to function as a dimer and to be oriented with its termini in the parasite cytosol. The key chloroq...Continue Reading

Citations

Nov 30, 2013·European Journal of Medicinal Chemistry·Pardeep SinghVipan Kumar
Sep 1, 2006·Journal of Medicinal Chemistry·Steven J BurgessDavid H Peyton
Jan 22, 2010·Journal of Medicinal Chemistry·Simeon AndrewsDavid H Peyton
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Spencer C MaughanChristopher S Cobbett
May 23, 2012·The Journal of Infectious Diseases·Carolina BustamanteChristian T Happi
Dec 3, 2010·PloS One·Mauro ChinappiAnna Tramontano
May 21, 2010·PLoS Pathogens·Stephanie G ValderramosDavid A Fidock
Dec 16, 2010·Future Microbiology·Ingrid B Müller, John E Hyde
Mar 29, 2013·Future Microbiology·Timothy J Egan, David Kuter
Jul 31, 2007·Future Microbiology·Leann TilleyPatrick G Bray
Jun 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kylie A MullinGeoffrey I McFadden
Jan 10, 2014·Memórias do Instituto Oswaldo Cruz·Gauri Awasthi, Aparup Das
Jan 31, 2012·Cellular and Molecular Life Sciences : CMLS·Robert L SummersRowena E Martin
Jul 9, 2011·Expert Opinion on Drug Metabolism & Toxicology·R Matthew Chico, Daniel Chandramohan
Mar 22, 2016·Tropical Parasitology·Hiasindh Ashmi Antony, Subhash Chandra Parija
Oct 20, 2004·Molecular Microbiology·Klaus LingelbachAndrew Waters
Jan 16, 2008·Molecular Microbiology·Cecilia P SanchezMichael Lanzer
Dec 22, 2009·The Journal of Eukaryotic Microbiology·Mark A Farmer, Andrea Habura
Dec 12, 2013·The Biochemical Journal·Kiaran Kirk, Adele M Lehane
Nov 19, 2014·Bioscience Reports·Rongwei TengKiaran Kirk
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Narinobu JugeYoshinori Moriyama
May 3, 2011·FEBS Letters·Ines PetersenMichael Lanzer
Oct 22, 2015·Annual Review of Microbiology·Kiaran Kirk
Sep 20, 2016·Nature Microbiology·Michelle Yi-Xiu LimPablo Bifani
Aug 12, 2015·The American Journal of Tropical Medicine and Hygiene·Liwang CuiPhilip J Rosenthal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.