The Malleable Nature of the Budding Yeast Nuclear Envelope: Flares, Fusion, and Fenestrations

Journal of Cellular Physiology
Rebecca A Meseroll, Orna Cohen-Fix

Abstract

In eukaryotes, the nuclear envelope (NE) physically separates nuclear components and activities from rest of the cell. The NE also provides rigidity to the nucleus and contributes to chromosome organization. At the same time, the NE is highly dynamic; it must change shape and rearrange its components during development and throughout the cell cycle, and its morphology can be altered in response to mutation and disease. Here we focus on the NE of budding yeast, Saccharomyces cerevisiae, which has several unique features: it remains intact throughout the cell cycle, expands symmetrically during interphase, elongates during mitosis and, expands asymmetrically during mitotic delay. Moreover, its NE is safely breached during mating and when large structures, such as nuclear pore complexes and the spindle pole body, are embedded into its double membrane. The budding yeast NE lacks lamins and yet the nucleus is capable of maintaining a spherical shape throughout interphase. Despite these eccentricities, studies of the budding yeast NE have uncovered interesting, and likely conserved, processes that contribute to NE dynamics. In particular, we discuss the processes that drive and enable NE expansion and the dramatic changes in the NE t...Continue Reading

References

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J Conde, G R Fink
Jan 1, 1982·Molecular & General Genetics : MGG·J Polaina, J Conde
Aug 1, 1994·The Journal of Cell Biology·L J KuriharaM D Rose
Feb 24, 1997·The Journal of Cell Biology·N Belgareh, V Doye
Mar 24, 1997·The Journal of Cell Biology·M Bucci, S R Wente
May 16, 1997·The Journal of Biological Chemistry·S Nishikawa, T Endo
Feb 7, 2001·Current Biology : CB·E M StoneS M Gasser
Jan 17, 2003·Molecular Biology of the Cell·Paul RobertsDavid S Goldfarb
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Sue L Jaspersen, Mark Winey
May 13, 2005·The EMBO Journal·Helena Santos-RosaSymeon Siniossoglou
Feb 10, 2006·The Journal of Biological Chemistry·Gil-Soo HanGeorge M Carman
Feb 10, 2006·Molecular Biology of the Cell·Joseph L CampbellOrna Cohen-Fix
Apr 22, 2006·Science·Maximiliano A D'AngeloMartin W Hetzer
May 9, 2006·Genome Biology·Bruce Futcher
Jun 17, 2006·Cell·Elizabeth J Tran, Susan R Wente
Jun 29, 2007·Molecular Biology of the Cell·Paul JorgensenBruce Futcher
Nov 14, 2007·The Journal of Cell Biology·Frank R Neumann, Paul Nurse
Nov 21, 2007·The Journal of Cell Biology·Patricia MelloyMark D Rose
Aug 15, 2008·Molecular Biology of the Cell·R KrickM Thumm
Feb 3, 2009·Autophagy·Roswitha KrickMichael Thumm
Mar 11, 2009·The Journal of Cell Biology·T Renee DawsonSusan R Wente
Jul 3, 2009·Molecular Biology of the Cell·Patricia MelloyMark D Rose
Aug 20, 2010·Chromosoma·Christine M Doucet, Martin W Hetzer
Oct 15, 2010·Molecular Biology of the Cell·Rosie Dawaliby, Andreas Mayer
Dec 8, 2010·The Journal of Cell Biology·Micah T WebsterOrna Cohen-Fix
Feb 8, 2011·Current Opinion in Cell Biology·Evgeny Onischenko, Karsten Weis
Feb 18, 2011·Nucleus·Dalibor MijaljicaRodney J Devenish
Apr 20, 2011·Cold Spring Harbor Symposia on Quantitative Biology·M CapelsonM W Hetzer

❮ Previous
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Citations

Sep 16, 2016·Molecular Biology of the Cell·Mahesh ChemudupatiStephen A Osmani
Mar 31, 2017·The Journal of Biological Chemistry·Thomas KupkeElmar Schiebel
Jun 22, 2018·Annual Review of Biochemistry·Charisma EnamRichard G Gardner
Mar 15, 2018·Nature·Seung Joong KimMichael P Rout
Jun 8, 2018·The Journal of Cell Biology·Tina L SingGrant W Brown
Mar 30, 2021·Current Genetics·Pallavi DeolalKrishnaveni Mishra

❮ Previous
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