The mammalian beta globin origin of DNA replication

Frontiers in Bioscience : a Journal and Virtual Library
Mirit I Aladjem

Abstract

Initiation of DNA replication is a tightly regulated process aimed to insure that the entire genome is replicated at the appropriate time during each cell cycle. In the human beta globin locus, replication initiates from a region between the two genes that encode the adult subunit of hemoglobin (the beta globin initiation region, or IR). Mammalian beta globin loci replicate early during the S phase of the cell cycle in pre erythroid cells, in which the beta-globin locus is present in a euchromatin form. However, in cells that do not express globin and in which the locus is heterochromatic, these same loci replicate during the later stages of S phase. Both early and late replication patterns utilize similar replication initiation regions. These features make the beta globin locus an attractive model for studying the determinants of replication sites and replication timing, as well as the correlation between gene expression and DNA replication. Two genomic domains are essential for initiation of DNA replication within the locus: the initiation region (IR), and a 40 kb region upstream of the globin gene cluster known as the locus control region (LCR). The IR meets the genetic requirements for a chromosomal replicator, since it can...Continue Reading

Citations

Sep 3, 2010·The EMBO Journal·Subhradip KarmakarSherman M Weissman
Apr 9, 2016·PloS One·Yining HuangChun Liang
Oct 3, 2007·Journal of Cellular Biochemistry·Milind C MahajanSherman M Weissman
May 1, 2010·Biomolecular Concepts·Claudia HagedornSina Rupprecht
Aug 17, 2006·The Journal of Biological Chemistry·Peijun LiuCyrus Vaziri

❮ Previous
Next ❯

Related Concepts

Related Feeds

© 2021 Meta ULC. All rights reserved