The Mammalian Microbiome and Its Importance in Laboratory Animal Research

ILAR Journal
André Bleich, James G Fox

Abstract

In this issue are assembled 10 fascinating, well-researched papers that describe the emerging field centered on the microbiome of vertebrate animals and how these complex microbial populations play a fundamental role in shaping homeostasis of the host. The content of the papers will deal with bacteria and, because of relative paucity of information on these organisms, will not include discussions on viruses, fungus, protozoa, and parasites that colonize various animals. Dissecting the number and interactions of the 500-1000 bacterial species that can inhabit the intestines of animals is made possible by advanced DNA sequencing methods, which do not depend on whether the organism can be cultured or not. Laboratory animals, particularly rodents, have proven to be an indispensable component in not only understanding how the microbiome aids in digestion and protects the host against pathogens, but also in understanding the relationship of various species of bacteria to development of the immune system. Importantly, this research elucidates purported mechanisms for how the microbiome can profoundly affect initiation and progression of diseases such as type 1 diabetes, metabolic syndromes, obesity, autoimmune arthritis, inflammatory ...Continue Reading

References

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Jan 20, 2012·Comparative Immunology, Microbiology and Infectious Diseases·André Bleich, Axel Kornerup Hansen
Jun 8, 2012·Science·Jeremy K NicholsonSven Pettersson
Aug 17, 2012·Nutrition Reviews·Luke K UrsellRob Knight
Aug 22, 2013·Gut Microbes·Alexander Sheh, James G Fox
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Feb 4, 2014·Inflammatory Bowel Diseases·Marijana BasicAndré Bleich
Feb 6, 2014·Laboratory Animals·UNKNOWN FELASA working group on revision of guidelines for health monitoring of rodents and rabbitsM Raspa
Jul 15, 2015·Inflammatory Bowel Diseases·Lydia M KeublerAndré Bleich
Aug 11, 2015·Journal of Advanced Research·Noha H YoussefMostafa S Elshahed
Sep 2, 2015·ILAR Journal·G HörmannspergerD Haller
Sep 2, 2015·ILAR Journal·Christoph BeckerStefan Wirtz
Sep 2, 2015·ILAR Journal·Aaron C Ericsson, Craig L Franklin
Sep 2, 2015·ILAR Journal·Kun LuJames G Fox
Sep 2, 2015·ILAR Journal·Andreas HiergeistAndré Gessner
Sep 2, 2015·ILAR Journal·Werner NicklasAndré Bleich
Sep 2, 2015·ILAR Journal·Axel Kornerup HansenCamilla Hartmann Friis Hansen

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Citations

Jun 2, 2017·Nature Protocols·Stefan WirtzMarkus F Neurath
Dec 12, 2018·Microbiology Resource Announcements·Marika ZiesackJeffrey Way
Mar 23, 2017·Lab Animal·Jerald SilvermanPatricia A Preisig
Jan 15, 2020·Mucosal Immunology·Dilini C GunasekeraJay H Bream
Jan 4, 2018·Lab Animal·Caroline J Zeiss, Cory F Brayton
Jul 17, 2018·Current Protocols in Immunology·Richard LavinLynn Bry
Aug 26, 2016·Nutrition & Metabolism·Maria KuleckaJerzy Ostrowski
Aug 10, 2018·Laboratory Animals·Randi Lundberg
May 18, 2019·Laboratory Animals·Marijana Basic, André Bleich
Jan 24, 2021·NPJ Biofilms and Microbiomes·Aurea Simon-SoroHyun Koo
May 21, 2021·The ISME Journal·Adrian GoreckiFabian Horn
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Stephanie Buchheister, André Bleich
Dec 3, 2021·Bulletin of Experimental Biology and Medicine·A V Semenov

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