PMID: 8600571Nov 1, 1995Paper

The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene?

Somatic Cell and Molecular Genetics
F LecomteC Szpirer

Abstract

The mammalian gene encoding the S6 ribosomal protein is the homolog of the Drosophila air8 tumor suppressor gene. We assigned the rat Rps6 gene to chromosome 5q22-33. The rat 5q22-33 chromosome region, previously shown to bear a malignant transformation suppressor gene, is homologous to the human 9p2l region, frequently deleted in various kinds of cancers and also containing at least one tumor suppressor (oncosuppressor) gene. To test the possibility that the Rps6 gene could be an oncosuppressor gene in mammals, we analysed its sequence and expression in normal and malignantly transformed cells. In mouse hepatoma cells (BWTG3), the Rps6 gene is hemizygously deleted but the remaining copy shows no sequence anomaly in the coding region, indicating that Rps6 is not oncosuppressor and that another gene acting as an oncosuppressor is located in its vicinity. In human tumor cells, the RPS6 gene is retained in cells showing deletion of the near-by gene, IFNB. Our results do not support the possibility that the RPS6 gene acts as an oncosuppressor gene in mammalian cells.

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J W FountainJ Lahti
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K L WatsonP J Bryant
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M O DiazJ D Rowley
Jan 1, 1986·Progress in Nucleic Acid Research and Molecular Biology·J A Traugh, A M Pendergast
Jun 25, 1987·Nucleic Acids Research·J L LalanneJ M le Moullec
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D N CarneyJ D Minna
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C V Glover
Nov 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M J Stewart, G Thomas
Jul 21, 1994·Nature·C H SpruckP A Jones
Jun 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C SzpirerJ Szpirer
Apr 1, 1993·Molecular and Cellular Biology·M J Stewart, R Denell

❮ Previous
Next ❯

Citations

May 29, 2002·Biochimica Et Biophysica Acta·Jishu WangHua Han
Oct 24, 2003·Biochimica Et Biophysica Acta·Sergio WittlinGeoffrey J Lindeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.