The mammalian tachykinin ligand-receptor system: an emerging target for central neurological disorders.

CNS & Neurological Disorders Drug Targets
Nick PantaleoStuart Maudsley

Abstract

Our understanding of the complex signaling neurophysiology of the central nervous system has facilitated the exploration of potential novel receptor-ligand system targets for disorders of this most complex organ. In recent years, many relatively neglected receptor-ligand systems have been re-evaluated with respect to their ability to potently modulate discrete tracts in the central nervous system. One such system is the tachykinin (previously neurokinin) system. The multiple heptahelical G protein-coupled receptors and neuropeptide ligands that comprise this system may be significantly involved in more central nervous systems actions than previously thought, including sleep disorders, amyotrophic lateral sclerosis, Alzheimer's disease and Machado-Joseph disease. The development of our understanding of the role of the tachykinin receptor-ligand system in higher order central functions is likely to allow the creation of more specific and selective tachykinin-related neurotherapeutics.

Citations

Feb 20, 2014·Medicinal Research Reviews·Dong GuoLaura H Heitman
Aug 10, 2016·Biochemical Pharmacology·I NederpeltL H Heitman
Mar 8, 2016·Journal of Inorganic Biochemistry·Reeha ShahzadChristopher E Jones
Sep 9, 2019·Analytical and Bioanalytical Chemistry·Zuzana JurasekovaArmida Torreggiani
Feb 12, 2021·The Journal of Physical Chemistry. B·Shira Ben-Shushan, Yifat Miller
Apr 20, 2021·Biological Psychiatry·A Shaam Al AbedNathalie Dehorter

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