The management of active surveillance in prostate cancer: validation of the Canary Prostate Active Surveillance Study risk calculator with the Spanish Urological Association Registry

Oncotarget
Á Borque-FernandoJuan Soto-Villalba

Abstract

The follow up of patients on active surveillance requires to repeat prostate biopsies. Predictive models that identify patients at low risk of progression or reclassification are essential to reduce the number of unnecessary biopsies. The aim of this study is to validate the Prostate Active Surveillance Study risk calculator (PASS-RC) in the multicentric Spanish Urological Association Registry of patients on active surveillance (AS), from common clinical practice. We find significant differences in age, PSA and clinical stage between our validation cohort and the PASS-RC generation cohort (p < .0001), with a reclassification rate of 10-22% on the follow-up Bx, no cancer was found in 43% of the first follow-up Bx. The calibration curve shows underestimation of real appearance of reclassification. The AUC is 0.65 (C.I.95%: 0.60-0.71). PDF and CUC do not suggest a specific cut-off point of clinical use. We select 498 patients on AS with a minimum of one follow-up biopsy (Bx) from the 1,024 males registered by 36 Spanish centers recruiting patients on the Spanish Urological Association Registry on AS. PASS-RC external validation is carried by means of calibration curve and area under de ROC-curve (AUC), identifying cut-offs of clin...Continue Reading

References

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Citations

Jul 24, 2020·Nature Reviews. Urology·Michelle M KouspouMark Buzza
Jan 1, 2021·Journal of Clinical Epidemiology·Shane D CollinsGlen P Martin
Dec 9, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Joseba SalgueroMaría José Requena

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Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT00756665

Software Mentioned

RC
R
PASS Risk Calculator ( PASS - RC )
PASS

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