PMID: 9451421Feb 6, 1998Paper

The management of crisis in sickle cell disease

European Journal of Haematology
I Okpala

Abstract

The symptoms and signs of sickle cell disease are exacerbated in times of crisis, characterized by tissue infarction or worsening anaemia. Prompt medical intervention is required in these distressing situations to provide relief and comfort to the patient. Effective analgesia is crucial in treating the painful crisis of sickle cell disease. The haemoglobinopathy may cause hyposthenuria with reduced ability to excrete the sodium load in normal saline. A 5% dextrose solution or 5% dextrose in 25% normal saline is therefore recommended for intravenous hydration. As the leading cause of morbidity and mortality in sickle cell disease, infections call for vigorous antibiotic therapy. Oxygen administration should be reserved for hypoxic patients, and blood transfusion given only when really indicated. Acute chest syndrome and cerebrovascular accidents are life-threatening complications of sickle cell disease whereas priapism can cause important long-term sequelae; all deserve urgent attention. In the long term, comprehensive care is cost-effective in reducing the frequency and adverse effects of sickle cell crisis.

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Citations

Apr 22, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Volker Schettler, Eberhard Wieland
Sep 23, 2014·Expert Opinion on Investigational Drugs·Iheanyi Okpala
Mar 28, 2019·American Journal of Hematology·Marcus A CardenUNKNOWN Sickle Cell Disease Arginine Study Group and the Pediatric Emergency Care Applied Research Network (PECARN)
Feb 12, 2019·Artificial Cells, Nanomedicine, and Biotechnology·William H NugentBjorn K Song
Jan 21, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Marcus A CardenWilbur A Lam
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C C AnyaegbuL S Salimonu
Aug 16, 2002·British Journal of Haematology·Iheanyi OkpalaBetty Cheung
Jul 26, 2000·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·L J McCarthyC F Danielson
Jul 7, 2009·Pediatric Hematology and Oncology·Anthony N IkefunaSunday Ocheni
Dec 23, 2004·European Journal of Haematology·Chukwuma EzehIheanyi Okpala
Jun 19, 2002·European Journal of Haematology·Iheanyi OkpalaIan Abbs
Sep 22, 2021·Journal of Translational Medicine·Tim JangSeah H Lim

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