PMID: 6356973Nov 1, 1983

The management of insulin dependent diabetes during cardiopulmonary bypass and general surgery

D J ThomasG M Rees


Two groups of insulin dependent diabetic subjects have been studied: six undergoing general surgical procedures and six undergoing hypothermic cardiopulmonary bypass surgery for coronary artery vein grafting. Intravenous glucose insulin mixtures were infused from the onset of surgery in both groups of patients, supplying 0.4 units of insulin per gram of glucose per hour, and 0.6 units of insulin per gram of glucose per hour in general and cardiac surgical patients respectively. Postoperatively diabetes was controlled carefully with an insulin syringe pump regulated by venous blood glucose monitoring. In cardiac surgical patients far more insulin was required to control diabetes postoperatively than in the general surgery patients (at 1 hour 1.6 units, SEM 0.4 compared to 0.7 SEM 0.1, p less than 0.05; and at 4 hours 2.0 units SEM 0.3 compared to 0.8 units SEM 0.1, p less than 0.02). Five non-diabetic subjects who underwent surgery for coronary artery venous bypass grafting were also studied. They developed significant postoperative hyperglycaemia (5.0, SEM 0.2, mmol/litre pre-operatively, compared with 8.8, SEM 0.7, mmol/litre p less than 0.03 at 1 hour and 10.2, SEM 1.7, mmol/litre, p less than 0.02 at 4 hours after bypass ter...Continue Reading


Dec 1, 1977·European Journal of Clinical Investigation·W S SoerjodibrotoS R Bloom
Feb 1, 1978·British Journal of Anaesthesia·D J Thomas, K G Alberti
Apr 18, 1970·Lancet·V A Kurien, M F Oliver
Jun 1, 1972·The American Journal of the Medical Sciences·J D BagdadeR J Bulger
Feb 1, 1973·Annals of Surgery·N L MillsF C Spencer
Mar 1, 1971·Annals of Surgery·R L Fulton, P Ridolpho
Feb 1, 1971·British Journal of Anaesthesia·S P Allison
Feb 1, 1966·The Journal of Clinical Investigation·D PorteR H Williams
Mar 21, 1981·British Medical Journal·S M WoodP Rogers
Oct 1, 1981·Diabetologia·E J Weringer, E R Arquilla


Mar 1, 1995·Journal of General Internal Medicine·R L Schiff, M A Emanuele
Apr 22, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Ohad CohenAram K Smolinsky
Feb 8, 2005·AORN Journal·Rebecca Ann LorenzJohn E Codd
Jun 13, 2003·Endocrinology and Metabolism Clinics of North America·Babette Carlson Glister, Robert A Vigersky

Related Concepts

Coronary Artery Bypass Surgery
Blood Glucose
Cardiopulmonary Bypass
Diabetes, Autoimmune
Glucose, (beta-D)-Isomer
Parenteral Infusion
Implantable Programmable Insulin Pump
Intraoperative Period
Postoperative Period

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