PMID: 11318802Apr 25, 2001Paper

The management of isolated thrombocytopenia in Chinese adults: does bone marrow examination have a role at presentation?

Clinical and Laboratory Haematology
Y K MakY C Chu

Abstract

We performed a retrospective analysis of bone marrow examination (BME) in the management of Chinese adult patients less than 60 years of age with isolated thrombocytopenia at presentation. Eighty-three patients with a median age of 39 years presenting with isolated thrombocytopenia (median platelet count: 38 x 10(9)/l) had routinely undergone BME as part of the laboratory investigations during the period from January 1996 to December 1999. All 83 patients had bone marrow findings of active marrow suggesting causes due to peripheral destruction. All of these patients responded to steroid or intravenous immunoglobulin (IVIg) therapy at presentation if their platelet counts were significantly low or if they had mucosal bleeding. Eighty-one of the 83 patients, after a median of 20 months follow-up, were finally diagnosed as having idiopathic thrombocytopenic purpura (ITP). The remaining two patients were finally confirmed as cases of systemic lupus erythematosus (SLE). Our results suggest that BME is not helpful in the diagnosis of isolated thrombocytopenia or suspected ITP in adult patients at presentation, provided that a thorough clinical history and physical examination are undertaken and that the blood count and peripheral blo...Continue Reading

References

Sep 1, 1987·American Journal of Epidemiology·A S LokH J Lin
Feb 15, 1997·Annals of Internal Medicine·R McMillan
Mar 27, 1999·The Medical Journal of Australia·J S Wiley
Mar 27, 1999·The Medical Journal of Australia·D A Westerman, A P Grigg
May 26, 1999·The New England Journal of Medicine·M L Heaney, D W Golde
Dec 22, 1999·Journal of Pediatric Hematology/oncology·T P Cripe

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Citations

Dec 12, 2003·Journal of Pediatric Hematology/oncology·Drew Provan, Adrian Newland
Nov 21, 2007·Journal of the American Veterinary Medical Association·Matthew D Miller, Katharine F Lunn
Nov 5, 2009·European Journal of Haematology. Supplementum·Drew Provan
Dec 12, 2003·Hematology·Adam J MeadDrew Provan
Feb 18, 2003·British Journal of Haematology·UNKNOWN British Committee for Standards in Haematology General Haematology Task Force
Jun 29, 2012·Platelets·Rohtesh S MehtaEnrico M Novelli
Apr 12, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Abhishek PurohitPravas Mishra
Feb 18, 2011·Blood·Cindy NeunertUNKNOWN American Society of Hematology
May 7, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Steven J Jubelirer, Robert Harpold

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