The Management of Opioid-Induced Nausea and Vomiting in Patients with Cancer: A Systematic Review

Journal of Palliative Medicine
Tonje A SandeMarie T Fallon

Abstract

Opioids are the foundation of treatment for cancer pain but can cause side-effects, one of the most common being nausea and vomiting, which can impair quality of life. To evaluate the evidence for the management of opioid-induced nausea and vomiting. This systematic review was undertaken as part of an update of the European Association for Palliative Care's opioid guidelines. Searches of MEDLINE (1966-2017) and EMBASE (1980-2017) were done. Key eligibility criteria were: randomized controlled trials conducted in patients with cancer. The Grading of Recommendations Assessment Development and Evaluations system was applied to formulate recommendations. Fifteen studies were eligible (1524 patients). The studies were grouped as follows: opioid switching (n = 8); the use of antiemetics to treat opioid-induced nausea and vomiting (n = 4); and change of route of administration of the opioid (n = 3). Three recommendations were formulated: A weak recommendation for switching from morphine to oxycodone in cancer patients with nausea (quality D); a weak recommendation for switching from tramadol to either codeine or hydrocodone for pain in cancer patients with nausea (quality D); and a weak recommendation for switching from morphine/oxyco...Continue Reading

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Citations

Mar 10, 2020·The Clinical Journal of Pain·César MargaritAna M Peiró
Jan 22, 2020·Current Oncology Reports·Rita J Wickham
Jan 27, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Raffaele GiustiLucilla Verna
Apr 21, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bixi NiuYong Chen
Aug 17, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mellar DavisEduardo Bruera
Sep 4, 2021·ESMO Open·G B CrawfordUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Aug 3, 2021·Journal of Hospice and Palliative Nursing : JHPN : the Official Journal of the Hospice and Palliative Nurses Association·Sachiko Okayama, Yoshinobu Matsuda

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Methods Mentioned

BETA
PCA
sedation

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