The management of patients with nonseminomatous germ cell tumors of the testis with serologic disease only after orchiectomy

The Journal of Urology
B E DavisGeorge J Bosl

Abstract

Management of patients with nonseminomatous germ cell tumors of the testis who have persistently elevated serum tumor marker levels (alpha-fetoprotein and/or human chorionic gonadotropin) following orchiectomy and no clinical evidence of disease is controversial. We reviewed our experience with 15 such patients at our cancer center between March 1977 and November 1991. Group 1 (11 patients) underwent initial retroperitoneal lymph node dissection and group 2 (4 patients) received primary chemotherapy. All group 1 patients required subsequent chemotherapy for retroperitoneal disease or persistent marker elevation, whereas only 1 of the 4 who received primary chemotherapy required later surgery. We conclude that tumor marker elevation in this setting is usually indicative of systemic tumor, which is best treated primarily by initial chemotherapy.

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Citations

Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F RabbaniG J Bosl
Mar 11, 2005·Expert Review of Anticancer Therapy·Gerald H YoonDonald G Skinner
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J StephensonJoel Sheinfeld
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy D GilliganUNKNOWN American Society of Clinical Oncology
Oct 21, 2009·BJU International·Andrew J Stephenson, Eric A Klein
Jan 31, 2013·Korean journal of urology·Yu Seob Shin, Hyung Jin Kim
May 21, 2013·Asian Journal of Andrology·Zhao-Jie LvZhi-Ming Cai
Jul 24, 1997·The New England Journal of Medicine·G J Bosl, R J Motzer
Oct 20, 2009·The Journal of Urology·Stephen B WilliamsJerome P Richie
Nov 18, 2006·International Urology and Nephrology·Zaza Mezvrishvili, Laurent Managadze
Apr 13, 2010·Nature Reviews. Urology·David J GallagherDean F Bajorin
May 18, 2021·Asian Journal of Urology·Christian Winter, Andreas Hiester
Jul 24, 2004·Urologic Oncology·Andrew J Stephenson, Joel Sheinfeld
Jan 7, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L H Einhorn, R S Foster
Jan 22, 2005·Critical Reviews in Oncology/hematology·Stefania GoriMaurizio Marangolo
Aug 30, 2005·European Urology·Peter AlbersGiorgio Pizzocaro

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