The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement

Journal of the National Comprehensive Cancer Network : JNCCN
Renato G MartinsDouglas E Wood

Abstract

Patients with stage IIIA non-small cell lung cancer, determined based on involvement of ipsilateral mediastinal lymph nodes, represent the most challenging management problem in this disease. Patients with this stage disease may have very different degrees of lymph node involvement. The pathologic confirmation of this involvement is a key step in the therapeutic decision. The difference in the degree of lymph node compromise has prognostic and treatment implications. Based on multiple considerations, patients can be treated with induction chemotherapy, chemoradiotherapy followed by surgery, or definitive chemoradiotherapy without surgery. Data derived from clinical trials have provided incomplete guidance for physicians and their patients. The best therapeutic plan is achieved through the multidisciplinary cooperation of a team specialized in lung cancer.

Citations

May 30, 2013·American Society of Clinical Oncology Educational Book·Christina S BaikRenato G Martins
May 21, 2015·American Society of Clinical Oncology Educational Book·Gavitt A Woodard, David M Jablons
Sep 23, 2016·Japanese Journal of Clinical Oncology·Kazuhiko Shien, Shinichi Toyooka
Jun 5, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ke-Neng ChenJie He
Jan 9, 2014·Expert Review of Anticancer Therapy·Tithi BiswasMitchell Machtay
Jan 20, 2019·World Journal of Surgery·Giovanni M ComacchioFederico Rea
May 19, 2020·General Thoracic and Cardiovascular Surgery·Stefano BongiolattiLuca Voltolini
May 27, 2014·American Society of Clinical Oncology Educational Book·Mark G KrisJamie E Chaft
Jul 14, 2016·Journal of Oncology Practice·Rafael Santana-Davila, Renato Martins
Jun 4, 2014·Journal of Surgical Oncology·Sumin ShinJhingook Kim
Mar 18, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gaetano RoccoDavid R Jones
Jan 1, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Chi-Fu Jeffrey YangMark F Berry
Nov 30, 2019·Expert Review of Respiratory Medicine·Giulia VeronesiPietro Bruschini
May 23, 2018·Interactive Cardiovascular and Thoracic Surgery·Pietro BertoglioMarco Lucchi
Dec 1, 2020·Critical Reviews in Oncology/hematology·Abdul Rahman JaziehKhaled Alkattan
Oct 4, 2015·The Journal of Thoracic and Cardiovascular Surgery·Chi-Fu Jeffrey YangMark F Berry
Jun 5, 2021·Journal for Immunotherapy of Cancer·Elizabeth AhernBrett G M Hughes
Jun 29, 2021·General Thoracic and Cardiovascular Surgery·Yohei KawaguchiMingyon Mun
Dec 23, 2020·The Annals of Thoracic Surgery·Giulio MauriziErino A Rendina
Jun 9, 2020·The Journal of Thoracic and Cardiovascular Surgery·Ke-Neng ChenJie He

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Nichole T TannerGerard A Silvestri
American Society of Clinical Oncology Educational Book
Christina S BaikRenato G Martins
© 2021 Meta ULC. All rights reserved