The management of superficial transitional cell carcinoma of the bladder

Urology
Shomik Sengupta, Michael M Blute

Abstract

Superficial transitional cell carcinomas (TCC) of the urinary bladder, defined as those that are restricted to the mucosa or the lamina propria, represent a common condition with a wide spectrum of biologic significance. High-grade superficial TCC, particularly in the presence of lamina propria invasion, has a significant risk of occult or subsequent progression to muscle-invasive or metastatic disease. Such high-risk lesions merit aggressive therapy with repeat resection followed by intravesical therapy, usually in the form of bacille Calmette-Guérin. Criteria for failure of intravesical therapy are not well defined, but persistent cytologic or cystoscopic abnormalities at 6 months are worrisome. Salvage intravesical therapy may sometimes be successful, but early cystectomy should be strongly considered, especially in younger patients. Close surveillance of patients with high-risk superficial TCC is essential.

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Citations

Aug 13, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Kamil CamAli Erol
Oct 7, 2011·Urology Annals·Bedeir Ali-El-DeinEl-Housseiny I Ibrahiem
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May 24, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Giampiero FrancicaMauro Maniscalco

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