The management of treatment-related esophageal complications in children and adolescents with cancer

Journal of Pediatric Surgery
Dave LalMichael P La Quaglia

Abstract

Serious treatment-induced esophageal strictures and tracheoesophageal fistulae are rare in the pediatric oncology population. This report details our experience with their management. We retrospectively reviewed our experience with pediatric oncology patients treated for esophageal complications over a 23-year period. Serious complications were defined as development of strictures requiring dilatation or an esophageal fistula. Fifteen patients were identified, 5 of which had been previously reported. Thirteen patients developed esophageal stricture, and 2 progressed to tracheoesophageal fistulae. The remaining 2 patients developed tracheoesophageal fistulae without antecedent stricture. The median interval from cancer diagnosis until development of esophageal complications was 3.5 years (range, 0.4-11.8 years). Before development of esophageal complication, 14 patients (93%) were treated with mediastinal radiation and 7 (47%) for candidal esophagitis. Strictures were most commonly located in the distal esophagus (5), then midesophagus (3), cervical esophagus (3) and diffusely (2). A median of 5 dilatations (range, 1-50) were necessary before patients were able to resume a normal diet. The origin of tracheoesophageal fistulae wa...Continue Reading

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Citations

Jun 1, 2010·Pediatric Radiology·Derek J Roebuck, Clare A McLaren
Nov 6, 2009·Journal of Pediatric Hematology/oncology·Melissa JessopMargaret Little
Feb 20, 2010·Journal of Pediatric Hematology/oncology·Kevin KellyAengus O' Marcaigh
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Dec 3, 2016·Pediatric Radiology·Susan C ShelmerdineSue C Kaste

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