The many faces of anxiety-neurobiological correlates of anxiety phenotypes

Psychiatry Research
Carmen AndreescuHoward Aizenstein

Abstract

Anxiety is an all-inclusive concept incorporating somatic symptoms (palpitations, dizziness, dyspnea), emotional and cognitive elements (negative affect, fear, worry, rumination) and behavioral components (e.g., avoidance). The aim of this study was to examine the specific neural correlates associated with anxiety phenotypes (worry, rumination, somatic anxiety) and negative affect (neuroticism). Twenty-nine anxious participants and 30 healthy controls were included in the study. We analyzed seed-based intrinsic connectivity and used correlation maps in a multivariable regression model to describe the specific effect of each anxiety phenotype independently of the effects of age and the other measures of anxiety. Worry severity was uniquely correlated with increased intrinsic connectivity between right anterior insula (RAI) and the precuneus. Global and somatic anxiety were associated with the limbic and paralimbic structures (increased connectivity between the amygdala, PVN, and hippocampus), while neuroticism was correlated with increased connectivity between limbic and prefrontal structures. Rumination severity did not correlate significantly with any measures of functional connectivity once we controlled for other clinical me...Continue Reading

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Citations

Oct 19, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Helmet KarimCarmen Andreescu
Sep 4, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Eric J Lenze, Meryl A Butters
Nov 9, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kevin J ManningDavid C Steffens
Jan 18, 2018·Journal of the American Geriatrics Society·Kevin J Manning, David C Steffens
Dec 14, 2018·Journal of Neurodevelopmental Disorders·Cynthia E RogersChristopher D Smyser
Sep 29, 2019·Journal of Psychiatric Research·Julia TomasiArun K Tiwari
Feb 10, 2021·Neurobiology of Aging·Helmet T KarimCarmen Andreescu
Feb 11, 2021·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Carmen Andreescu
Jun 29, 2021·Behavioural Brain Research·Brandee FeolaJennifer Urbano Blackford

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