The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.
Associated Clinical Trials
Elevated interleukin-1 release by human alveolar macrophages during the adult respiratory distress syndrome
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial
Sodium selenite and N-acetylcysteine in antiretroviral-naive HIV-1-infected patients: a randomized, controlled pilot study
Oxidatively modified proteins in bronchoalveolar lavage fluid of patients with ARDS and patients at-risk for ARDS
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
Bench-to-bedside review: Damage-associated molecular patterns in the onset of ventilator-induced lung injury
Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response
Successful use of intravenous N-acetylcysteine in dengue haemorrhagic fever with acute liver failure
Targeting the gut-lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection
Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19).
The association of hypertension and diabetes pharmacotherapy with COVID-19 severity and immune signatures: an observational study.
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease
Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases
Immune Parameters and COVID-19 Infection - Associations With Clinical Severity and Disease Prognosis
Hypercoagulopathy and Adipose Tissue Exacerbated Inflammation May Explain Higher Mortality in COVID-19 Patients With Obesity
Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?
Immunomodulation Through Low-Dose Radiation for Severe COVID-19: Lessons From the Past and New Developments
Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology
A child with a severe multisystem inflammatory syndrome following an asymptomatic COVID-19 infection: A novel management for a new disease?
Understanding immunopathological fallout of human coronavirus infections including COVID-19: Will they cross the path of rheumatologists?
Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes
Identification of Novel Candidate Epitopes on SARS-CoV-2 Proteins for South America: A Review of HLA Frequencies by Country
The Role of Imaging in the Management of Suspected or Known COVID-19 Pneumonia. A Multidisciplinary Perspective
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